Medication

Antipyrine

  • Structure
  • Release form
  • pharmachologic effect
  • Pharmacodynamics and pharmacokinetics
  • Indications for use
  • Contraindications
  • Side effects
  • Antipyrine, instructions for use (Method and dosage)
  • Overdose
  • Interaction
  • Terms of sale
  • Storage conditions
  • Shelf life
  • Analogs
  • Reviews
  • Price, where to buy

Structure

In 1 tablet 0.25 g phenazone.

Release form

0.25 g tablets

Pharmachologic effect

Antipyretic, analgesic.

Pharmacodynamics and pharmacokinetics

 

Pharmacodynamics

Antipyrine- analgesicderivative pyrazolone; is having antipyretic, analgesic and anti-inflammatoryact. Its activity is close to Salicylic acid. The effects produced are associated with the ability to inhibit COX1 and COX2 and disrupt the synthesis of arachidonic acid. The active substance reduces the permeability of capillaries and has hemostaticlocal action.

A 10-20% solution is prepared from the powder, which is used as hemostatica remedy for nosebleeds, applying tampons moistened in a solution. Technical Antipyrine is used in the synthesis Amidopyrine and Analgin.

 

Pharmacokinetics

Quickly absorbed from the digestive tract. The maximum concentration is determined after 1-2 hours. Metabolized relatively slowly. About 5% is excreted in an unbound form, and 30-40% doses binds to Glucuronic acid.

Indications for use

As part of complex therapy Antipyrineit is applied when:

  • neuralgia;
  • rheumatism;
  • joint pain;
  • feverish conditions;
  • various pain syndromes.

Contraindications

  • hypersensitivity;
  • aspirin bronchial asthma;
  • renal/liver failure;
  • gastric ulcer;
  • active liver disease;
  • pregnancy;
  • hyperkalemia

Caution is prescribed when Ischemic heart disease, diabetescerebrovascular diseases hyperlipidemiain old age.

Side effects

Antipyrine may cause:

  • allergic reactions;
  • urticaria;
  • agranulocytosis;
  • tachycardia;
  • depressed;
  • collapse.

Antipyrine, instructions for use (Method and dosage)

Tablets are taken orally 0.25-0.5 g 2-3 times a day. In this case, a single dose is not more than 1 g, and the daily dose is 3 g.

For nosebleeds, swabs moistened with a 10-20% solution are used. It is made from powder.

To reduce the risk of reactions from the gastrointestinal tract, it is necessary to apply the minimum dose in a short course.

Overdose

No information available.

Interaction

Manifestations of hematotoxicity are enhanced with the appointment of myelotoxic drugs. Concomitant use of corticosteroids, anticoagulants, antiplatelet agents, is not recommended, Fluoxetine, Sertraline, Paroxetine.

Terms of sale

Without recipe.

Storage conditions

Temperature up to 30 ° С.

Shelf life

3 years.

Analogs

Matches for ATX Level 4 code:AnaldimReopyrinTempalginBenalginPentalgin ICNPentalgin NPentalginAnalginTetralginSpasmalineMaxiganSedal MPiralginBaralgin MSedalgin PlusRevalginAndipal

Azofen, Piralgin, Anodinine, Pyrazine, Pyrazoline, Metosin, Phenyl, Sedatin, Phenazone, Paracetamol, Pentalgin,Santoperalgin, Pentabufen.

Reviews

Antipyrinewas the first synthetic analgesic of the pyrazolone series, synthesized in 1883. Currently not applicable, but is available in the range of medicines. How is the substance used in analytical chemistry. The pharmaceutical market has different antipyretics, but not all of them are used in children. The requirements for an antipyretic drug for the treatment of this age category are more stringent. Phenacetin, Antipyrine, Amidopyrine- contraindicated for use in pediatric practice because of their nephrotoxicityand hematoxicity. For the same reasons, adults are prescribed a short course. There have been cases of pigmented toxidermia, purpura, and Lyell syndrome after taking this drug. Since it has not been used in clinical practice for a long time, there are no reviews about it.

Price, where to buy

To get Antipyrinein the pharmacy network is not possible.

  • Online Pharmacies in Russia

ZdravCity

  • Iodantipyrine tab. 100mg n50Pharmstandart-Tomskkhimfarm OAO / Aveksima Sibir OOO419 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Iodantipyrine 100 mg No. 50 tablPharmstandart-Tomskkhimfarm, OAO530 rub.order
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