The drug Bicillin-1 contains the active substance: benzatine benzylpenicillin.

The composition of Bicillin-3, except benzathine benzylpenicillinalso include benzylpenicillin novocaine saltand benzylpenicillin sodium.

Bicillin-5 contains benzatine benzylpenicillia and benzylpenicillin novocaine salt.

Release form

Bicillin is available in the form of a powder for the preparation of an injection solution, which is intended for i / m administration. The drug is packaged in 10 ml glass vials.

Pharmachologic effect

Bicillin has bactericidal and antibacterialaction.

Pharmacodynamics and pharmacokinetics

The activity of this drug is aimed at various gram-positive microorganisms, anaerobic spore-forming bacilli, some gram-negative microorganisms and so on. The effectiveness of Bicillin against pathogen viruses does not appear polio, smallpox, flu, fungi, most gram-negative microorganisms, as well as strains that produce penicillinase.

With the / m introduction of Bicillin-1, its slow absorption was noted. Then the drug hydrolyzes, releasing benzylpenicillin, which will continue to enter the bloodstream. The maximum concentration is achieved after 12-24 hours, and the therapeutic effect is manifested after 3-6 hours.

Slow release hydrolysis is also characteristic of Bicillin-3. benzylpenicillin. A single injection allows you to maintain a therapeutic concentration in the blood for 6-7 days, the maximum concentration is reached after 12-24 hours from the time of administration. At the same time, a high penetration of the substance into physiological fluids was established, and low - into the tissue. Also, the drug passes through the placental barrier, passes into breast milk. To a small extent, the drug is biotransformed, excretion mainly occurs through the kidneys.

As a result of the intramuscular administration of Bicillin-5, its increased concentration in the blood is detected already in the first hours. In this case, the therapeutic effect lasts from 28 days.

Indications Bicillin

The main indications for the use of Bicillin are the treatment of various infectious diseases that cause microorganisms sensitive to the drug.

Therefore, the drug is prescribed for:

  • acute tonsillitis;
  • scarlet fever;
  • wound infections;
  • erysipelas;
  • rheumatism;
  • syphilis, frambesia, leishmaniasis and so on.


The drug is not prescribed for hypersensitivityto its components and others penicillins.

Caution should be exercised during treatment of patients with bronchial asthma, hay fever, urticaria and others allergic diseasesintolerance to various drugs.

Side effects

During treatment with Bicillin, various side effects may develop that affect the activity of the cardiovascular system and blood formation, manifesting itself in the form anemia, thrombocytopenia, leukopenia and hypocoagulation.

Also possible allergic reactionsFor example: irritation and rash on mucous membranes and skin, hivesjoint pain exfoliative dermatitis, swellingand so on.

Common undesirable manifestations are not excluded: headache, fever, arthralgia, glossitis, stomatitispain at the injection site. Long-term therapy can cause superinfection, the causative agents of which are microorganisms and fungi that are resistant to the drug.

Bicillin - instructions for use (Method and dosage)

According to the instructions for the use of Bicillin-1, this drug is used as a prophylactic and therapeutic agent for infectious diseases. Moreover, the features of the introduction are that the injections are done deeply, in the upper part of the gluteal muscle. The dosage and treatment regimen for various conditions is established by the attending physician.

Bicillin-3 instructions for use recommends introducing in a dosage of 300,000 units, if necessary, in different buttocks. Repeat the injection after 3 days, in the end, you can enter in 6 days to 600,000 units. Primary or secondary therapy syphilis involves the introduction of a single dosage of 1.8 million units. In total, they make 7 injections according to a certain scheme: the first and second, 300,000 units every day, then 2 times a week. Other diseases, according to indications, also involve the use of certain dosages, regimens, and duration of treatment.

Bicillin-5, instructions for use recommends to be administered at a dose of 1.5 million units once a month for adult patients, 600 thousand units every 3 weeks for children under 8 years old, 1.2-1.5 million units 1 once a month - for children from 8 years.

Preparation of the suspension is allowed strictly before use, subject to aseptic conditions. In the annotation for each type of drug, it is accurately described how to breed and how to breed Bicillin-5 and so on. Typically, the contents of the vial are dissolved in sterile distilled water, 0.9% sodium chloride solution, or 0.25-0.5% novocaine solution. Then the resulting mixture is well shaken and immediately introduced.

This drug is also actively used in veterinary medicine. It is suitable for cats and dogs, and this treatment is used to treat fish and small mammals.


No cases of overdose in clinical practice have been reported.


Concomitant use of this drug with bactericidal antibiotics, eg: cephalosporins, cycloserine, vancomycin, rifampicin, aminoglycosides may cause synergistic effect. Combination with bacteriostatic agents: macrolides, chloramphenicol, lincosamidesand tetracyclines causes antagonistic effect.

In addition, a decrease in efficiency oral contraceptives or ethinyl estradiol. Reduce tubular secretion or increase the concentration of the drug may diuretics, phenylbutazone, allopurinol and NSAIDs. Combination with allopurinol often causes allergic reactions, mainly in the form of skin manifestations.

Special conditions

Before starting treatment, you need to clarify how to breed Bicillin-3 or other types of the drug. Usually a prescription is written in Latin, so it is best to immediately find out from the doctor how to inject the medicine, at what dosage and other features of the therapy.

If blood appears in the syringe during the injection, it means that the needle has entered the blood vessel. In such cases, you need to remove the syringe and make an injection in another place. After that, the injection site is pressed with a cotton swab, but do not rub it.

Discontinuation of therapy requires development allergic reactions, regardless of the form of manifestation.

During the treatment of sexually transmitted diseases, especially syphilis, before the start of therapy and in the next 4 months, microscopic and serological studies should be performed.

To prevent the development of fungal infections, it is recommended to take B vitamins and FROM, as well as nystatin and levorin. When the drug is used in insufficient dosages or therapy is terminated prematurely, this can cause the development of resistant strains of pathogens.

Applying Bicillin-3 in veterinary medicine, you also need to consider all the appointments of specialists for animals, which have many features.

Terms of sale

The medicine is prescription.

Storage conditions

A dry, dark, cool place inaccessible to children is intended for storing the drug.

Shelf life

3 years.


Matches for ATX Level 4 code:Benzylpenicillin sodium saltPhenoxymethylpenicillinExtensillinRetarpenBenzylpenicillinSulacillin

The main analogues are represented by drugs: Benzatin benzylpenicillin, Benzicillin, Moldamine, Retarpen and Extensillin.


In the treatment with Bicillin, drinking alcohol is not recommended, as this can significantly reduce or enhance the therapeutic effect.

Reviews about Bicillin

In most cases, reviews about Bicillin-5 are found on various medical forums and sites, the topic of which is related to the treatment of infectious diseases that require a long stay inside the body.

As reviews on Bicillin-3 show, this drug is prescribed in the treatment of various ENT infections. Moreover, almost always the therapy is quite successful.

Nevertheless, before proceeding with treatment with this antibiotic, it is necessary to check the sensitivity of the pathogen to this medicine.

In addition, during treatment with Bicillin, allergic reactions. If they manifest complex side effects, then the drug is canceled. In any case, both the appointment and the abolition of treatment remain the responsibility of the attending physician.

Bicillin price, where to buy

You can buy this drug in pharmacies or online pharmacies.

At the same time, the price of Bicillin-5 in the form of a powder for the preparation of a suspension is from 10 rubles per bottle.

The price of Bicillin-3 varies between 7-10 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan


  • Bicillin-3 pores preparation. susp. v / m enter. 200 + 200 + 200 thousand units 10ml №50Synthesis OJSC2608 rub.order

Pharmacy Dialog

  • Bitsillin-3 (fl. 600 thousand units) 74 rubles to order
  • Bitsillin-3 (fl. 1200000ED) 51 rub.order
  • Bitsillin-5 (fl. 1500000ED) 81 rub.order
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  • Bicillin-3 KMP 600,000 powder for suspension PAT "Kyivmedpreparat", Ukraine38 UAH order
  • Bicillin-5 KMP 1.500.000 UNITS powder for suspension PAT "Kyivmedpreparat", Ukraine51 UAH order

Pani Pharmacy

  • Vetbicillin-5 pores. d / pr susp. d / in. 1500000U Ukraine, Basalt 12 UAH order
  • BICILLIN-3 bottle Bicillin-3 pores. d / in. 600000ED Ukraine, Kievmedpreparat OAO 48 UAH to order
  • BICILLIN-5 bottle Bicillin-5 pores. d / in. 1500000ED Ukraine, Kievmedpreparat OAO 52 UAH to order
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  • Bitsillin-5 1500000 PIECES No. 1 (50 pieces in box.) Then. d / in.f. Synthesis of OJSC (Russia) 235 tg.order
  • Bitsillin-3 600000 units of No. 1 then. d / in.f. Synthesis of OJSC (Russia) 240 tenge
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