Histamine Dihydrochloride


The active component of the drug is histamine dihydrochloride.

An additional component is purified water.

Release form

The medicine is sold in bottles.

Pharmachologic effect


Pharmacodynamics and pharmacokinetics

About histamineswhat it is and what is their effect on the body, you should know in order to understand the mechanism of action of histamine dihydrochloride. Histamine- this is one of mediatorsthat take part in the regulation of significant body functions and play a significant role in pathogenesis a number of painful conditions. The formula is C5H9N3. Usually, histaminepresent in the body in a bound, inactive state. Its content increases with various pathological conditions: injuries allergic manifestationsstress. Then other biologically active substances, such as serotonin, acetylcholine, prostaglandins, bradykininsubstance anaphylaxisand others. Level histamineincreases with the intake of various toxins and certain medications, it is also found in products.

In the human body there are also special receptors called histamine - H receptors. They have different localization. With stimulation H1 receptors the tone of smooth muscles of the intestine, bladder, bronchi increases. Stimulation H2 receptors promotes secretion of the glands of the stomach, relaxes the smooth muscles of the uterus, controls the function of the salivary glands. Histamine receptors responsible for regulation HELLpermeability of capillaries and coronary vessels.

What histamine and what foods it contains, it is important to know for proper nutrition. Usually they have a long shelf life. In some cases, their intake should be limited. Here are some foods that contain histamine:

  • alcoholic drinks;
  • smoked meat and sausages;
  • yeast;
  • soy, tofu, beans;
  • pickled vegetables;
  • long-ripening cheeses;
  • fish and seafood (especially canned);
  • coffee;
  • cocoa;
  • Wheat flour;
  • Strawberry;
  • bananas
  • pineapples
  • kiwi;
  • citrus;
  • pears.

In medical practice, histamine dihydrochloride is used. It provokes smooth muscle spasms, decreased pressure, increased secretion of gastric juice, expansion of capillaries, increased heart rate.

Act histamine on skin cell receptors causes local vasodilation and edemaare formed papules and nerve endings are stimulated. Provokes itchy skin and neurogenic hyperemia. A test is conducted with histamine for skin diagnostics allergic diseases.

Indications for use

Indications for use of this tool are as follows:

  • polyarthritis;
  • allergy;
  • pain due to lesion peripheral nerves;
  • articular and muscular rheumatism;
  • migraine;
  • diagnostics hypersecretorystomach conditions.

The drug is used for staging skin tests for diagnosis. allergies.


Skin tests are not performed for any skin disease. This tool is also not used in case of severe heart disease, hypotension and vascular dystoniarespiratory diseases (including history), uncompensated renal impairment, expressed hypertension, pheochromocytomas. Among the contraindications, in addition, it appears pregnancy, breast-feeding, childhood.

Side effects

Skin tests do not cause adverse reactions. With a normal skin reaction, itchingto reduce it, after evaluating the test results, the injection site can be washed with water.

In addition, this tool may cause headache, dizziness, fainting, tachycardiafacial flushing, shortness of breath, hypertensionnervousness, rush of blood, cramps, bronchospasm. At higher dosages, probable cyanosis, dyspneapronounced decrease blood pressure, nausea, cramping in the abdomen and stomach, metallic taste, blurred vision, unpleasant or painful sensations in the chest, diarrhea, disorders of the gastrointestinal tract, swelling or redness at the injection site.

Instructions for use of Histamine Dihydrochloride (Method and dosage)

Skin tests are carried out only after obtaining the written informed consent of the patient. They are placed on the inner surface of the forearm. The distance between the samples should be 20-40 mm. There are no age limits for the test.

Histamine dihydrochloride vials are used in compliance with the rules. asepsis. Drops of the solution are applied to the disinfected skin. Sterile disposable lacent for prik test individual for each patient. Through a drop of histamine dihydrochloride are held injections to the limit stop lancet.

At scarification tests 5 mm long scratches are applied through a drop of solution. Sterile scarifiers individual for each patient.

The results are evaluated after 20 minutes according to a special table. The skin reaction to Histamine Dihydrochloride should be positive. If the reaction is negative, test with allergens do not set.

In other cases, the instructions for use of Histamine Dihydrochloride indicate that the solution is being administered subcutaneously, intramuscularly and intradermally 0.1-0.5 ml each.


With an overdose of the drug, maintenance is carried out airwayas well as application Mechanical ventilationand oxygen if necessary. When injections impose a tourniquet near the injection site in order to slow the absorption of the active substance in blood. Possible introduction antihistaminesmedicines, 0.3-0.5 mg uhpinephrine hydrochloride subcutaneously for therapy hypotension(up to 2 times every 20 minutes).


Drug interaction with other drugs is not described.

Terms of sale

Sold by prescription only.

Storage conditions

Store the drug in a dark place at room temperature.

Shelf life

5 years. Duration of use of a closed dropper cap 0.01% solution histamine for skin tests, provided that it is stored in the refrigerator - 1 year and not longer than the total shelf life indicated on the bottle.


Reviews about this drug are not so common. There are no negative ones among them. This allows you to characterize Histamine Dihydrochloride as an effective tool if used according to the instructions.

Price of Histamine Dihydrochloride

The price of Histamine Dihydrochloride in the pharmacy network is about 50 hryvnias or 170 rubles.

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