1 capsule contains omeprazole 10, 20 or 40 mg.

Release form

Gelatin Capsules 10 mg, 20 mg, 40 mg

Pharmachologic effect

Inhibition of acid formation, has cytoprotectiveact.

Pharmacodynamics and pharmacokinetics


Irreversibly binds to the enzyme H + / K + -ATPase, known as the proton pump. It inhibits its activity, which leads to a decrease in basal and stimulated secretion. The effect of the drug depends on the dose. The effect appears after 1 hour, and the maximum - after 2 hours and lasts 24 hours. At the end of treatment, secretion returns to normal within a week. When taking 20 mg, acidity decreases by 90% and by 94% when taking 40 mg.


Absorption occurs in the small intestine within 3-6 hours. Cmax in the blood after 0.5-1 hours. Bioavailability is 35%. Bioavailability increases in the elderly and with impaired liver function. Metabolized in the liver. It is excreted by the kidneys (70%) and with bile (30%).

Indications for use Ultopa

  • gastroesophageal reflux;
  • erosive gastritis and duodenitisarising from the use of NSAIDs;
  • peptic ulcer;
  • Helicobacter pylori eradication (in complex therapy);
  • stress and peptic ulcers;
  • Zollinger-Ellison syndrome.

Indications for use of 10mg capsules:

  • symptoms dyspepsia (e.g. heartburn);
  • short-term therapy;
  • anti-relapse treatment;
  • prevention ulcersand erosionwhen taking NSAIDs.


  • pregnancy and lactation;
  • individual intolerance omeprazole;
  • age up to 12 years;
  • hereditary fructose intolerance;
  • simultaneous reception with atazanavir;
  • severe kidney and liver diseases;
  • the presence of the patient glucose galactose malabsorption.

Side effects

  • diarrhea or constipation, flatulencedry mouth vomiting, stomatitistransient increase in liver enzymes;
  • insomnia, headacheexcitement dizziness, depression, hallucinations, encephalopathy (with severe liver diseases);
  • tachycardia, angina pectorisincrease in blood pressure, peripheral edema;
  • interstitial nephritis, the appearance of protein, red blood cells and sugar in the urine, increased creatinine in blood;
  • in men, an increase in the mammary glands and pain in the testicles;
  • cramps, arthralgiabone pain myalgia;
  • agranulocytosis, thrombocytopenia, anemia, leukopenia, neutropenia;
  • dry skin itchingrash alopecia;
  • coughing, nosebleeds;
  • visual impairment, tinnitus;
  • fatigue, weakness, weight gain.

Ultop, instructions for use (method and dosage)

Capsules are taken orally without chewing before meals with a small amount of liquid. The duration of admission is determined by the doctor.

With exacerbation duodenal ulcer - 20 mg / day.

At GERD - 20 mg, in severe GERD 40 mg before breakfast with the transition to maintenance treatment.

At peptic ulcer and esophagitis- 20-40 mg / day.

Erosionwhile taking NSAIDs - 20 mg / day.

Helicobacter pylori eradication - 20 mg 2 r / day. in combination with antibacterial agents. For the purpose of prevention - 10 mg / day.

Zollinger-Ellison Syndrome - start taking 60 mg / day. Possible increase to 120 mg / day.

Instructions for use Ultopa should be followed to avoid overdose and side effects.


It was found that patients tolerate a dose of up to 360 mg.

When an overdose appears nausea, drowsiness, dizziness, tachycardia, blurred vision, increased sweating, agitation, in rare cases - cramps.

The treatment is symptomatic.


May decrease absorption ampicillin, ketoconazole, iron salts. Increases concentration diazepam, neodicumarin, syncumar, phenylinethat requires a reduction in the doses of these drugs. When taking with clarithromycin blood concentrations of both drugs increase.

Terms of sale

Released by prescription.

Storage conditions

At temperatures up to 25 ° C.

Shelf life

3 years.

Special instructions

Ultop is recommended to be taken before meals, as eating somewhat slows down absorption. If there are difficulties with swallowing the capsule, its contents can be mixed with juice and a suspension.

In children who take the drug for a long time, the level may decrease Vitamin B12.

In view of the sucrose content, Ultop is not recommended for patients with glucose-galactose malabsorption syndrome.

In normal dosages, the drug does not affect the reaction rate when driving a vehicle, however, it should be remembered that it is possible dizziness, visual impairment and drowsiness.

Analogs of Ultopa

Matches for ATX Level 4 code:HairabesolNofluxLantsidBarolBeretOntimeGastrozoleOmeprazolePantoprazoleProxyLansoprazoleZulbeksEpicurusSoarsLosek MapsLosekSunprazEmaneraOmez InstaOmez

Gastrozole, Losek, Omeprazole, Omez, Ulkazol, Bioprazole, Ornatol. All of these Ultopa analogues have the same active substance.

Ultop Reviews

Ultop: reviews of doctors

According to the reviews of practitioners, in the treatment of acid-dependent diseases it is better to take high-quality generics, which include Ultop. Among the omeprazoles presented in Russia, only this drug has bioequivalence with the original omeprazole, which has been proven in German laboratories.

In clinical trials in the gastroenterological department of MONIKI them. M.F. Vladimirsky Ultop has shown high efficiency in combination with clarithromycinand amoxicillinduring anti-Helicobacter therapy. Its clinical effectiveness is manifested in the rapid relief of symptoms (primarily heartburn) and the healing of erosive and ulcerative defects. After treatment, a long remission occurs.

Patient Reviews They say that Ultop is a combination of efficiency, good tolerance and reasonable price.

Ultop price, where to buy

You can buy the drug in pharmacies, a list of which is presented on the website of the Federal Information Service Information is updated daily. The price of Ultop 20 mg No. 28 ranges from 148 rubles. up to 337 rub.

  • Online Pharmacies in Russia


  • Ultop caps. Ksh / solution 10mg n28Krka-Rus OOO167 rub.order
  • Ultop caps. Ksh / solution 20mg n28Krka-Rus OOO283 rub.order
  • Ultop caps. Ksh / solution 40mg n28Krka-Rus OOO434 rub.order

Pharmacy Dialog

  • Ultop (caps. 20mg No. 28) 301 rub.order
  • Ultop (caps. 20mg No. 14) 149 rub.order
  • Ultop (caps. 10mg No. 28) 188 rub.order
  • Ultop (caps. 40mg No. 28) 485 rub.order
  • Ultop (caps. 40mg No. 14) 254 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Ultop 20 mg No. 28 capsKKRA-Rus OOO318 rub.order
  • Ultop 20 mg n14 capsKKRA-Rus OOO152 rub.order
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