Differin Composition

Gel Differin for external use contains the following components:

  • adaptal- 1 mg per 1 g of the pharmaceutical preparation;
  • propylene glycol;
  • methyl parahydroxybenzoate;
  • phenoxyethanol;
  • carbomer 940 P;
  • disodium edetate;
  • polycamera 182;
  • sodium hydroxide;
  • purified water.

Composition 1 g cream:

  • adaptal- 1 mg;
  • carbomer 974 P (934 P);
  • macrogol methyldextrose sesquistearate;
  • glycerol;
  • natural squalene;
  • methyldextrose sesquistearate;
  • edetate disodium;
  • methyl parahydroxybenzoate;
  • propyl parahydroxybenzoate;
  • phenoxyethanol;
  • cyclomethicone;
  • sodium hydroxide;
  • purified water.

Release form

In pharmacy kiosks and personal care cosmetic stores, the pharmaceutical product is presented in two forms:

  • Gel for external use white in plastic tubes of 30 g each. A cardboard box contains 1 tube and instructions for use.
  • Cream for external use in aluminum tubes of 30 g each. An annotation and 1 tube with medicinal ointment are put in a cardboard box.

Pharmachologic effect

Differin cream and gel, as a variation of one drug, belong to the group anti-inflammatoryand comedolytic agentsthat are used externally. The therapeutic effect develops thanks to the main active ingredient called adaptalbeing a metabolite retinoid. The biologically active substance normalizes the processes of keratinization and epidermal differentiation at the cellular level.

Differin Cream Against Black Dots selective mechanism the development of favorable effects, which consists in the interaction of the active component with specific receptors of epidermal skin cells, as a result of which weakening of cellular connections in the mouths of the sebaceous hair follicles and the elimination of etiological factors for micro comedones.

Along with the above mechanism of action, one should not forget that Adapalene has strong anti-inflammatory properties, because a component of a pharmaceutical slows down migration white blood cells into the focus of inflammation and metabolism of arachidonic acid, which "turns off" the leukocyte link from the pathological process.

Pharmacodynamics and pharmacokinetics

Both forms of the drug are intended for topical application to the skin and exposure to epidermal skin cells, because the absorption of active ingredients from the surface of the treated area is very low. Excretion of the absorbed part of biologically active substances occurs mainly through bile.

Indications for use

  • acne or acne;
  • acne vulgaris;
  • black dots;
  • comedones.


  • hypersensitivity to the active and auxiliary components of the pharmaceutical preparation;
  • hereditary or acquired intolerance to the drug and its constituent elements;
  • dermatitis;
  • eczema;
  • skin neoplasms;
  • childhood;
  • period of pregnancy and breastfeeding;
  • damage to the skin;
  • burn wound surface;
  • the use of systemic drugs from the group retinoids.

Side effects

In the process of conservative treatment with a pharmaceutical agent, the development of:

  • irritation of the skin at the treatment site;
  • rednessand skin peeling;
  • sensation itching or burning;
  • dry skin;
  • local physiological change pigmentation;
  • contact dermatitis;
  • eczema;
  • allergic conjunctivitis.

If these side effects are observed, it is strongly recommended that you immediately suspend further rehabilitation and consult a qualified dermatologist. It should also be noted that a drug increases the risk of developing sunburn at a normal level of solar radiation.

Instructions for Differin (Method and dosage)

Gel Differin, instructions for use

Before applying the gel for acne is necessary clean face, so the therapeutic capabilities of the pharmaceutical will be much higher. However, you should not use alcohol or soap solutions for this, it is recommended to use shower gel. The ointment is applied in a uniform thin layer over the entire face (if Differin is used from blackheads) or selectively only on inflammatory elements to eliminate them, it is not rubbed.

The frequency of use is once a day, it is better to use the drug in the evening, before bedtime, since at night the reparative mechanisms of the skin are higher due to the activity of the parasympathetic nervous system. The maximum effect of applying the gel is usually observed after a month, but the full course of conservative therapy for getting rid of black spots or acne lasts 3 months. The possibility of reorganization with a pharmaceutical preparation must be additionally discussed with a dermatologist.

Cream Instruction

Like gel, acne and acne cream should be applied to clean and dry skin with light touches. You can use the cream both in the morning and in the evening. Avoid contact with the pharmaceutical product on the red border of the lips, nasal mucosa and eye area, otherwise the possibility of developing side effects of local and systemic nature increases significantly. The cream is used not only for the skin of the face, but also for the back, shoulders and chest area, if there is such a need (acne rash or other defects are common).


condition intoxication active or auxiliary components are unlikely, since Differin has a low ability to absorb (only 4% of the applied amount of ointment or gel is absorbed into the microvasculature). In case of accidental oral use or application of the drug to damaged skin, prolonged uncontrolled use, the following symptoms may develop:

  • dry skin;
  • muscle pain;
  • lacrimation;
  • symptoms of poisoning vitamin a in especially severe cases.

Terms of sale

In pharmacy kiosks and beauty shops, the drug is dispensed without a prescription.

Storage conditions

Adapalene, the main active substance of the cosmetic product Differin, is resistant to light, oxygen and is inactive in the chemical plan, so storing the drug is easy. Both gel and cream should be preserved at a temperature of 25 degrees Celsius out of the reach of children.

Shelf life

2 years with the cream for external use and 3 years with 0.1% gel.

Special instructions

After prescribing a pharmaceutical product, most patients wonder what is better - Differin cream or gel. Both forms of the drug contain the active active ingredient in equal amounts, and therefore their therapeutic properties do not differ. What about auxiliary active substances - based on their combination, it can be argued that the cream, as a rule, is indicated for more sensitive and dry skin, since biological components can improve trophism to some extent, however, their beneficial effects develop gradually due to the specificity of chemical interactions.

Analogs of Differin

Matches for ATX Level 4 code:AdaklinIsotrexinAdapaleneEffezelKlenzitRetinoic OintmentRetin ARadevitWe see

Differin analogs are medicines or cosmetics that have similar therapeutic capabilities aimed at combating acne, black spots, or other skin defects. Among the entire group of similar pharmaceutical products, of which there are many, it should be noted domestic preparations, the acquisition of which in the countries of the former CIS does not create difficulties. These include: gel Klenzitointment Video systemsointment Radevitsolution Retasolcream diaconel.

The price of Differin analogues of domestic production, of course, is lower, which, as a rule, is a key factor in choosing a pharmaceutical product. However, Differin is a premium drug manufactured in France, the world center of cosmetology, and there is no doubt in its effectiveness.

Which is better: Baziron or Differin?

Baziron - benzene peroxide antiseptic in gel form for external use. The mechanism of the therapeutic effect of the pharmaceutical preparation is a pronounced antimicrobial effect directed against skin colonies staphylococcusand propionobacteria, the main causative agents of acne. Also, the drug saturates the skin oxygen, normalizing trophic processes, and inhibits the synthesis and secretion of excretion of the sebaceous glands, so that the skin becomes softer, moisturized and pathological hyperemia disappears.

It is difficult to compare the data of pharmaceutical preparations, since the mechanism of their action is extremely different, although the therapeutic orientation of the application is similar, therefore, qualified dermatologists have developed a conservative treatment regimen acnewhen Baziron and Differin are used together in a combined rehabilitation. Thus, beneficial effects develop earlier, and persistent remission lasts much longer.

Skinoren or Differin - which is better?

Like Baziron, Skinoren belongs to the group of antiseptic drugs. The main active component of the gel is azelaic acid, which has an antimicrobial effect. In addition, the active component affects follicular hyperkeratosis, inhibiting the proliferation of keratinization and normalizing the rate of final differentiation of epidermal elements. Separately, it is worth noting that the pharmaceutical preparation reduces the number of fractions of free fatty acids in the lipid structures of the skin, which eliminates the problem of oily skin.

Although preparations Skinoren, Differin, Diaknel, Klenzit, etc. are analogues, still they - different drugs with different composition and pharmacological effects, so it is best to choose which drug is right for you, with the help of a specialist.

During pregnancy and lactation

It is contraindicated for use during breastfeeding or pregnancy due to the possible development of an overdose of vitamin A and subsequent adverse effects on the baby.

Differin reviews

The pharmaceutical preparation belongs to imported cosmetics that have high therapeutic efficacy, therefore, undoubtedly the reviews about Differin from acne are positive in their overwhelming majority. The active component allows not only to cleanse the skin of the face, back, shoulders and chest from unpleasant, and sometimes ugly, rashes, but also helps to normalize the trophic and plastic properties of the surrounding tissue, which with acne cannot but be considered one of the aspects “for” the pharmaceutical preparation.

Reviews about Differin cream from qualified dermatologists only confirm the good recommendations and opinions of people who used the gel or cream. Adapalen, the main active component, carefully regulates the processes of keratinization and differentiation of epidermal cell structures at the biochemical level, which is confirmed in the process of repeated clinical studies.

Of course, reviews of Differin gel are often overshadowed by the high cost of the drug, since it is made from the best constituent components and is an imported cosmetic product. However, such a price is completely reasonable, because after passing the full course of conservative rehabilitation in 3 months, biologically active components can achieve stable remission for many years.

Differin price, where to buy

The price of Differin gel is practically independent of the country in which the cosmetic product is purchased, since the drug is produced in France, the world center of the pharmaceutical industry, and therefore has truly premium characteristics.

So, the price of Differin in Ukraine averages 350 hryvnias for cream and 450 hryvnias for gel for external use.

The price of Differin cream in the Russian Federation is equivalent to that in Ukraine, however, in the pharmacy kiosks of the immense state there is no such significant difference between the cost of cream and gel. For example, in Novosibirsk, both forms of a pharmaceutical product can be purchased for 600-650 rubles.

The cost of a cosmetic product in Belarus is in great question because of the difficulties of translating into national currency and other economic amendments, because how much a pharmaceutical drug costs in a pharmacy should be found by visiting a licensed point of sale.

  • Online Pharmacies in Russia


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