1 ampoule contains 15 ml of a colorless solution with a vinegar odor, which corresponds to 0.9 grams cyanamide (in one drop - 3 mg of the active substance).

Additional components: glacial acetic acid, sorbic acid, water for injection, sodium acetate.

Release form

The solution is available in ampoules of 15 ml of dark glass. In a pack of cardboard there is a special bottle with a dropper-dispenser, 1 plastic tray, which contains 4 ampoules, and instructions from the manufacturer.

Pharmachologic effect

What is Colme? This is a cure for alcoholism.

The active ingredient inhibits the enzyme acetaldehydrogenasewho is actively involved in the process metabolism ethyl alcohol. Cyanamide increases the level of acetaldehyde - ethyl alcohol metabolite, which leads to the development of negative symptoms when alcohol enters the human body.

Shortness of breath, palpitations, flushing of the face, nausea are observed.

At the level of conditioned reflexes, an aversion to the smell and taste of alcohol-containing drinks is formed.

Compared to Disulfiram cyanamide does not record a hypotensive effect.

The sensitizing effect of the active component on ethyl alcohol appears after 45-60 minutes and lasts almost 12 hours.

Pharmacodynamics and pharmacokinetics

The manufacturer does not provide data for this section.

Indications for use

Colme Drops are prescribed for the treatment of patients suffering chronic alcoholism. The drug is also used to prevent relapse after a cure for alcoholism.


Contraindications for drops:

  • severe course of cardiovascular disease;
  • pathology of the hepatic system;
  • lactation;
  • kidney disease;
  • individual hypersensitivity;
  • pregnancy.

Side effects of Colme

The medicine is well tolerated. The following side effects are rarely recorded:

  • transient leukocytosis;
  • increased drowsiness;
  • feeling of tiredness;
  • noise in ears;
  • skin rashes.

The medicine is well tolerated if the patient complies with the doctor’s prescription and does not take alcohol-containing drinks. How to neutralize side effects? Stop drinking alcohol completely. Ethyl alcohol reaction:

  • a feeling of pronounced pulsation in the neck and head;
  • flushing of the skin;
  • nausea;
  • pain behind the sternum;
  • blurred visual perception;
  • weakness;
  • heart palpitations;
  • increased sweating.

In severe cases, it develops:

  • collaptoid state;
  • the fall blood pressure
  • vomiting
  • depression of respiratory function.

The severity of adverse reactions depends on the amount of alcohol. With a pronounced clinical picture, the appointment is recommended antihistaminescarrying out measures to maintain the cardiovascular system and breathing. It is recommended to cancel the drug Colme.

Colme, instructions for use (Method and dosage)

Drops from alcoholism can be prescribed only after a thorough examination of the patient. The attending doctor should warn the patient about the development of possible complications and consequences.

Instructions on Colma

According to an individual scheme, the drug is taken daily at 36-75 mg (12-25 drops twice a day). Drops are dosed as follows: the contents of the ampoule after opening are poured into a bottle in a cardboard box. A special dropper must be put on the bottle. If long-term storage is required, the bottle is tightly closed.

Instructions for use Colme Light

5 ml (teaspoon) three times a day with meals.

How to take drops? Daily for 1 month.


A specific clinical picture is not described, an increase in the severity of negative reactions is possible. Syndromic therapy and activities aimed at maintaining the heart and respiratory system are recommended. In severe cases, a blood transfusion may be required.


The anti-alcoholic drug Kolme is incompatible with medicines of the aldehyde group (products chloral and paraldehyde).

Mandatory time-lapse between applying Colme and Disulfiram is 10 days.

Medicines that can enhance the reaction to alcohol:

  • Phenytoin;
  • Isoniazid;
  • Metronidazole.

Terms of sale

Drops of Colma from alcoholism can be purchased at the pharmacy by presenting a prescription medical form with seals.

Storage conditions

The manufacturer has limited storage temperature - 15-25 degrees.

Shelf life

2 years.

Special instructions

Additionally, a medication is available Colme Lightwhich prevents breakdowns after successful therapy of alcoholism. The medicine allows you to consolidate the result and returns the patient vitality and appetite during rehabilitation.

Analogs of Colme

Matches for ATX Level 4 code:AntaxonMethadoxylAntabusVivitrolNaltrexoneMedichronalDisulfiramTeturamProproten-100LidevinEsperal

Drug substitutes for the pharmacological effect:

  • Lidevin;
  • ProProTen-100.

Structural analogues are not developed.

During pregnancy and lactation

The drug for alcohol is prohibited for use when bearing of pregnancy and breastfeeding.

Reviews about Colma (opinion of doctors and patients)

The medicine is widely used in the treatment of alcohol dependence. Reviews of drops of Colma are mostly positive. Relatives of patients write that they gave drops from alcoholism, without warning their relatives who are addicted. And after some time, a complete refusal to take alcohol-containing drinks was noted against the background of a significant deterioration in well-being after taking even small doses of ethyl alcohol.

Treatment alcoholism difficult, and in most cases it is possible if the patient is motivated and really wants to get rid of the bad habit.

Reviews about Colme Light positive. Reviews of doctors about the drug Colme Light confirm the effectiveness of the drug in the treatment of alcohol dependence.

Price Colme, where to buy

The price of drops of Colma from alcoholism varies in the range of 1200-1500 rubles. The price of Colme Light varies in the range of 1000-1200 rubles.

In Moscow, a cure for alcoholism can be bought for 1400 rubles.

The price of Colme in Ukraine is 350-500 UAH for 4 ampoules, in Dnepropetrovsk - 400 UAH. You can buy Colma in Kiev for 370 UAH.

In Belarus, the drug costs 360 thousand Belarusian rubles.

  • Online Pharmacies in Russia

Eurofarm * 4% discount on the promotional code medside11

  • Mizo drops 15 ml n4 fl (analog colme) SPECIAL PRODUCTS LINE S.P.A. 2390 rub.order
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