Medication

Minoxidil

Structure

The preparation contains the active substance - Minoxidil.

The solution also includes additional components: alcohol, propylene glycol, water.

Release form

Minoxidil is produced in the form of an odorless powder, which is readily soluble in propylene glycol, ethanol, methanol, propanol, water and some other liquids. In the finished solution with a concentration of the active substance of 2%, 5% and 15%, foam, spray and tablets.

Pharmachologic effect

Minoxidil has hypotensive, vasodilating and stimulatingaction against hair growth.

Pharmacodynamics and pharmacokinetics

This drug is able to activate potassium channels in the membrane region of smooth muscle cells of the vascular walls. Minoxidil is characterized by a peripheral vasodilating effect, which dilates resistive vessels, reduces the load on the myocardium, and leads to reflex tachycardia and increased cardiac output. Also, the activity of plasma renin in the composition of the blood increases, there is a delay in sodium and water.

The stimulating effect of the drug on hair growth was noted in the case of androgen-dependent alopecia. It is believed that vasodilation and improved microcirculation in the skin and hair follicles contribute to enhanced hair growth. The maximum effect is manifested in the treatment of a disease that lasts less than 10 years in young patients, the size of the bald head is up to 10 cm. At the same time, the majority of patients suffering from the disease up to 3-5 years achieve a positive result.

A noticeable effect of the treatment manifests itself after 4 months, subject to daily local use of the solution. Cancellation of therapy leads to the cessation of growth of new hair, and after 3-4 months, the restoration of previous bald patches is not ruled out.

When taken orally, an almost complete absorption of the drug was noted. Maximum concentration is achieved within an hour. Inside the body, the drug practically does not come into contact with plasma proteins. The active ingredient may pass into breast milk. In the liver, the substance is biotransformed into inactive metabolites. Excretion occurs with the help of the kidneys.

When used locally, approximately 1.4% of the drug is absorbed on intact skin. When the use of Minoxidil is stopped, the process of its excretion takes about 4 days with the help of the kidneys.

Indications for use

The drug in tablets is prescribed for:

  • arterial hypertension, mainly in severe forms, as part of combination therapy with other antihypertensive agents.

It is recommended to use external solution for:

  • male pattern baldness in women and men.

Minoxidil for beard

To improve bristle growth, Minoxidil 5% is usually used, which Wikipedia characterizes as a “male” remedy. When the solution is applied to the skin, vasodilation occurs, which increases blood microcirculation. Due to this, the nutrition of the hair follicles increases, which contributes to the growth of hair growth from cannon to terminal. Of course, while this much depends on the characteristics of the person. With the same application of the solution for the beard in some people, the effect manifests itself in the first month, while others notice the growth of bristles only after 3-4 months.

As a rule, in order for the drug to not only contribute to the development of the terminal stage, but also to fix the effect, it may take 1-1.5 years.

Contraindications

You should abandon the use of tablets with:

  • hypersensitivity;
  • lactation, pregnancy;
  • pheochromocytoma;
  • mitral stenosis;
  • secondary pulmonary hypertension

The drug in solution is not recommended for use with:

  • violation of the integrity of the skin;
  • dermatosis scalp.

Minoxidil side effects

During the use of this drug, various side effects can develop that can affect the work of any system or organ. The nervous system and sensory organs are especially often affected, which is accompanied by dizziness, headache, visual impairmentand so on.

For the cardiovascular system and hematopoiesis it is characteristic: decrease in pressure, development tachycardia, arrhythmias, heart failure angina pectoris pericardial effusion, thrombopenia, leukopenia.

In addition, various undesirable manifestations on the skin and scalp are possible: hypertrichosis, increased pigmentation, the development of dermatitis, eczema, folliculitis and etc.

Instructions for use of Minoxidil (method and dosage)

The tablets are intended for oral administration. According to the instructions for Minoxidil, the initial daily dose for adults and children from 12 years old is 5 mg per 1-2 doses. If necessary, the dosage is gradually increased.

In this case, the average maintenance daily dose is 10-40 mg. For a day, you can take no more than 100 mg. For children under 12 years of age, the drug is prescribed once, the initial dose is calculated from 0.2 mg per kg of weight. The average therapeutic dose is 0.2-1 mg per kg of weight, the maximum allowable dosage is 50 mg per kg of weight.

Minoxidil external solution for hair should be applied to the dry surface of the scalp 2 times a day for 1 ml of the product. At the same time, it should be carefully rubbed, starting application from the center of the damaged area.

Overdose

With an overdose of the drug, excessive vasodilation, chest painexpressed hypotension, arrhythmia, tachycardia, neuritisas well as a delay in the body of sodium and water.

In such cases, symptomatic and supportive treatment is performed.

Interaction

Concomitant use with nitrates, diuretics, beta-blockers may enhance the hypotensive effect. Combination with estrogens, oral contraceptives, sympathomimetics and NSAIDs may weaken the effect of minoxidil. Combination with guanethidineas it may cause orthostatic hypotension.

Terms of sale

The drug is dispensed without a prescription.

Storage conditions

Storage conditions for Kirkland Minoxidil do not require special conditions. Therefore, the drug can be in a normal room, and the bottles are provided with a sealed lid that is difficult to open for children.

Shelf life

2 years.

Analogs

The main analogues are represented by drugs: Regein, Dualgen 15%, Spectral CSN.

Alcohol

The instruction for the drug does not contain information on the permissibility of its simultaneous use with alcohol. It is known that Minoxidil powder is highly soluble in ethanol, which is part of the solution for external use.

Reviews about Minoxidil

This drug is distributed in many countries, but Russia and Ukraine acquire it especially actively. As a rule, reviews of it are confirmation of the selective action on different patients. Some people report that the treatment was highly effective, and they achieved excellent results. Moreover, women's reviews of Minoxidil are much more common than reviews of men.

In most cases, reviews of Minoxidil for hair report that a solution with a 5% concentration is often used by women. They say that they noticed the effect of the drug after about three months - thin hairs began to appear in the affected areas, gradually darkening and thickening.

Also, Minoxidil for hair is used by men, who often describe a positive effect. At the same time, they specify that they expected it for several months, but even after that the hair grew slowly, but noticeably.

However, there are reports of such patients on whom treatment did not work at all. Users say that they precisely followed the instructions, used the solution for a long time, but did not specify the indication for use. The fact is that it is prescribed exactly when androgenetic alopeciathat only a specialist can diagnose.

Minoxidil price, where to buy

The price of Minoxidil in pharmacies depends on the established course of therapy. For example, in a Moscow pharmacy Kirkland Minoxidil 5% for 1 month can be purchased at a price of 900 rubles, and for 12 months from 7300 rubles.

You can buy a hair preparation in St. Petersburg in ordinary pharmacies or order on the Internet. You can buy Minoxidil 15% at a cost of 2,300 rubles.

The price of Minoxidil in Ukraine for 1-12 bottles is 199 - 1995 UAH.

  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

Pharmacy24

  • Minoxidil Inteli 60 ml solution Industrial Pharmaceutical Cantabria, S.A., Spain 417 grn. Order
  • Minoxidil Inteli 2% 60 ml No. 1 solution INDUSTRIAL Pharmaceutical Cantabria, S.A., Spain 306 UAH order
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BIOSPHERE

  • Minoxidil Inteli 2% 60 ml solution d / out. applic. in vial.Industrial Farmaceutica Cantabria S.A. (Spain) 5 tg.order
  • Minoxidil Intel 5% 60 ml solution d / out. applic. in vial.Industrial Farmaceutica Cantabria S.A. (Spain) 6 tg.order
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