The active substance of the drug is cortisone acetate. Additional components - sugar, stearic acid, potato starch.

Release form

The medicine is available in tablets. There are also suspension and ointment with cortisone, which are called Hydrocortisone.

Pharmachologic effect

The drug affects protein and carbohydrate metabolism. Renders catabolic and anabolic effect on protein synthesis. Also it desensitizing, immunosuppressive, anti-inflammatory and antiallergicmeans.

Pharmacodynamics and pharmacokinetics

In humans and animals hormone cortisonewhat it is and what processes it affects, it is important to know to understand the principle of action of the drug. Cortisone - This is a hormone of the adrenal cortex. It is a poorly soluble crystal that is secreted by the adrenal gland. Hormone cortisone stimulates the synthesis of carbohydrates and proteins, inhibits lymphoid organs. In industry, it can be obtained from steroids animal and vegetable origin.

The drug Cortisone affects protein and carbohydrate metabolism in the body. It reduces the total level of protein in plasma, enhances the breakdown of protein in the muscles and at the same time helps in its synthesis from the breakdown products in the kidneys and liver. Thus, in some tissues, protein formation is inhibited, and in others, on the contrary, accelerated. This action is realized through its effect on nucleic acids.

In addition, this tool controls the cleavage process. amino acidsin the liver.

Of great importance in its activity is a decrease in activity hexokinase. He activates glucose-6-phosphatase and thereby increases the flow of glucose into the bloodstream, and also activates the synthesis gluconeogenesis. This leads to an increase in the synthesis of carbohydrates from amino acids that appear during the breakdown of proteins, a decrease in glucose tolerance, and an increase in the level of glycogen in the liver and muscles.

Absorption carbohydrates increase in the intestines, while their consumption by muscles decreases.

The medicine also helps break down lymphoid tissue and inhibition of connective synthesis. It prevents manifestation allergic reactions and blocks synthesis hyaluronidase.

The drug also affects lipid metabolism. It accelerates the synthesis of higher fatty acids, while preventing the mobilization of fat. It also helps in sodium retention and enhanced potassium excretion.

Indications for use

Cortisone suspension and tablets are used in case of chronic adrenal insufficiency. In addition, this tool can be used for rheumatism, collagenoses, acute myeloid and lymphoblastic leukemia, hemolytic anemia, viral hepatitis, collapse and shockedcaused by various factors bronchial asthma, neurodermatitis and other skin diseases infectious mononucleosis, glomerulonephritisacute pancreatitis.


This tool should not be used when hypersensitivity to its components, as well as in the following cases:

  • renal failure;
  • gastrointestinal tract diseases - recently created intestinal anastomosis, gastric and duodenal ulcer, gastritis, diverticulitis, esophagitis, peptic ulcer, ulcerative colitis at risk perforation or abscessing;
  • parasitic and infectious diseases - simple herpes, chickenpox,, measles, amoebiasis, systemic mycosis, strongyloidosis, tuberculosis;
  • 8 weeks and 14 days after vaccinations;
  • immunodeficiency;
  • lymphadenitisafter vaccination BCG;
  • CCC diseases - severe arterial hypertensionrecent myocardial infarctiondecompensated chronic heart failure, hyperlipidemia;
  • endocrine system diseases - Cushing's disease, diabetes, hypothyroidism, thyrotoxicosis;
  • propensity for thromboembolism;
  • nephrourolithiasis;
  • myasthenia gravis;
  • polio (Besides bulbar encephalitis);
  • liver failure;
  • hypoalbuminemia, as well as the risk of its occurrence;
  • obesity of the III-IV degree;
  • syphilis;
  • glaucoma;
  • pregnancy;
  • elderly age;
  • recently transferred operations.

Side effects

Side effects depend primarily on the duration of the drug and dosage.

When taking this drug, the following negative effects on the body are possible:

  • endocrine system - Itsenko-Cushing's syndrome, steroid diabetes, a decrease in glucose tolerance, inhibition of the adrenal glands, delayed sexual development in childhood, manifestation of latent diabetes;
  • ССС - arrhythmia, heart failurepressure increase thrombosis, bradycardiaindicators on ECGcharacteristic of hypokalemia, hypercoagulation. When acute and subacute myocardial infarction likely enlargement of the focus necrosis and slow formation of scar tissue, which can cause rupture of the heart muscle;
  • metabolism - increased excretion of potassium from the body, weight gain, increased sweating, hypocalcemiaincreased protein breakdown, fluid retention and Na +, hypokalemic syndrome, hypernatremia;
  • skin - delayed wound healing, ecchymoses, hyper- or hypopigmentation, striae, petechiaethinning of the skin, steroid acne, tendency to pyoderma and candidiasis;
  • gastrointestinal tract - vomiting, nausea, pancreatitis, erosive esophagitis, change appetite, hiccups, steroid ulcer of the stomach and duodenumbleeding and perforation Gastrointestinal tract flatulence;
  • CNS - posterior subcapsular cataract, hallucinations, delirium, euphoria, affective insanity, paranoiaincreased anxiety, dizziness, pseudotumor cerebellum, cramps, increased intraocular pressure, which can lead to damage to the optic nerve, depressiontrophic changes of the cornea, disorientationincreased intracranial pressure, sleep disturbance, vertigo, headachea tendency to develop secondary eye infections, exophthalmos;
  • musculoskeletal system - tendon rupture, growth retardation and ossification processes in childhood, osteoporosis, steroid myopathy, atrophy muscle
  • allergy - generalized and local allergic reactions.

In addition, the following side effects are possible: the development or exacerbation of infections, withdrawal syndrome, leukocyturia.

In rare cases, there is an increase in activity transaminase liver and alkaline phosphatase.

Instructions for use of Cortisone (Method and dosage)

Pill medicine is used orally. Suspension used intramuscularly.

Instructions for use of Cortisone in the form of tablets recommends starting daily with a dose of 0.1-0.2 g. In total, 3-4 doses should be done per day. The dosage is gradually reduced to a minimum, which allows you to maintain a therapeutic effect. This is usually 0.025 g daily. At rheumatism consume 3-4 g.

The medicine is administered intramuscularly every day 1-2 times at a dose of 0.025-0.05 g. After one infusion you need to wait 8-12 hours.

When Addison's disease application combined with Deoxycorticosterone. In this case, sodium chloride is also introduced. The recommended daily dose of Cortisone is 12.5-25 mg, 4-10 g of sodium chloride, 1-5 mg of deoxycorticosterone acetate.

Maximum dosages of Cortisone for adult patients:

  • at a time - not more than 0.15 g;
  • in one day - no more than 0.3 g.

For children, the drug is indicated in lower dosages. They are calculated individually depending on the severity of the disease.

As a rule, young children are given 12.5-25 mg of the drug 3 times a day for 2 days. Then the medicine should be taken only 2 times / day. The dosage is gradually reduced to the minimum, able to maintain a therapeutic effect.

For children, the drug can be used both in the form of tablets and in the form of suspensions for intramuscular injection.

Strict medical supervision is required. Patients are preliminarily carefully examined for possible contraindications. Be sure to keep track of blood picture, HELL, state of the nervous system, weight, blood glucose level.


When taking the drug in high doses, adverse reactions intensify. Symptoms may appear. hypercorticism. Specific antidote no. Therapy is symptomatic.


This drug enhances the effect. antiplatelet agents and anticoagulants. In addition, it increases the likelihood of adverse reactions. cardiac glycosides, estrogen, steroid anabolics, asparaginase, NSAIDs, steroid androgen, amphotericin B.

Cortisone also reduces effectiveness diuretics, hypoglycemic funds and antihypertensive preparations.

Terms of sale

The medicine is sold by prescription.

Storage conditions

Keep the drug in a place protected from light at room temperature. Be sure to protect from small children.

Shelf life

Five years.


Antibacterialcortisone drugs receive mostly positive feedback from patients. They characterize the drug Cortisone in all forms of release as an effective medicine that helps with many diseases. It should be noted, however, that it has a lot of side effects, which, judging by the reviews, appear more often than when using other glucocorticosteroid funds.

Cortisone price, where to buy

The price of cortisone in tablets of 0.025 g for 80 pieces per pack is approximately 680 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

LuxPharma * special offer

  • Hydrocortisone France tablets 10mg No. 251490 rub. Order


  • Hydrocortisone-pos ointment 1% 2.5g n1Ursapharm Arzneimittel GmbH72 order
  • Hydrocortisone-pos ointment 2.5% 2.5g n1Ursapharm Arzneimittel GmbH82 RUB
  • Hydrocortisone ointment d / ex. approx. 1% tube 10gOzone LLC30 rub.order
  • Hydrocortisone Richter Susp. d / joint and okolosust. enter 25mg + 5mg / ml 5ml n1OAO Gideon Rich200 rub.order

Pharmacy Dialog

  • Hydrocortisone ointment (tube 1% 10g) 23 rub.order
  • Hydrocortisone ointment (tube hl. 0.5% 3g) 28 rub.
  • Hydrocortisone-Richter (suspension d / sust / okolosust. 25 mg + 5 mg / ml 5 ml 185 rubles order
  • Hydrocortisone ointment (tube 1% 10g) 33 rub.order
  • Hydrocortisone ointment (tube hl. 0.5% 5g) 36 rub.

Eurofarm * 4% discount on the promotional code medside11

  • Hydrocortisone ophthalmic ointment 0.5% 5 g THCP 35 rub.
  • Hydrocortisone ointment 1% 10 g nizhfarmNizhpharm AO32 rub.order
  • Hydrocortisone ointment 1% 10 g Ozone29 rub.order
  • Hydrocortisone ophthalmic ointment 0.5% 3 g TathimpharmTathimpharmaceuticals OJSC31 rub.order
  • Hydrocortisone Richter Injection Suspension 25 mg / ml 5 ml No. 1 bottle OAO Gideon Richter 220 rub.order
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  • Hydrocortisone Acetate 25mg / ml N10 Suspension for injection PAT "Pharmstandard-Biolik", Kharkiv, Ukraine98 uah. Order
  • Hydrocortisone Acetate 2.5% 2 ml No. 10 PAT "Farmak", Ukraine159 UAH
  • Hydrocortisone 0.5% 3 g ophthalmic ointment Pharmaceutical plant Elfa A.T., Polshcha68 uah order
  • Hydrocortisone 1% 10 g ointment BAT "Nizhpharm", metro Nizhny Novgorod, Rosіyska Federatsiya40 UAH order
  • Hydrocortisone-PIC 1% 2.5 g ophthalmic ointment Ursapharm Artsnaymitel GmbH, Nimechchina92 UAH order

Pani Pharmacy

  • Hydrocortisone ointment Ointment hydrocotisone-pos. 1% 2.5g Germany, Ursapharm 105 UAH order
  • Hydrocortisone ointment Hydrocortisone ointment ointment 0.5% 3g Poland, Jelfa 89 UAH order
  • Hydrocortisone ampoule Hydrocortisone acetate d / in. 2.5% 2ml №10 Ukraine, Pharmstandard-Biolek 114 UAH to order
  • Hydrocortisone ampoule Hydrocortisone acetate d / in. 2.5% 2ml №10 Ukraine, Farmak OAO 174 UAH order
  • Hydrocortisone ointment Ointment hydrocortisone 1% 10g Russia, Nizhpharm 42 UAH order
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  • Hydrocortisone 5 ml Suspension d / in. Gedeon Richter (Hungary) 990 tg.
  • Hydrocortisone 0.5% 5 g ointment ointment. Synthesis of OJSC (Russia) 240 tg.
  • Hydrocortisone 1% 10 g ointment in a tubeBiosynthesis (Russia) 230 tg.order
  • Hydrocortisone-AKOS 1% 10 g ointment in a tubeSynthesis OJSC (Russia) 240 tg.order
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