Medication

Droperidol

Structure

One milliliter of the drug contains 2.5 ml droperidol.

Droperidol release form

The medicine is released in the form of a clear liquid in ampoules of 5 or 12.5 ml. In cardboard boxes of 10 ampoules, in cardboard bundles of 5 contour plastic packaging.

Pharmachologic effect

Antishock, antiemetic, antipsychotic.

Pharmacodynamics and pharmacokinetics

Pharmacological group of droperidol - antipsychotic group butyrophenones. The duration of action of the drug does not exceed 2-3 hours, however, the effect of the drug occurs quickly and is quite strong. The medicine has the ability to potentiate the effect on the body of sleeping pills and painkillers. Possesses anti-shockand antiemetic activity.

Droperidol exerts adrenolytic action by locking central dopamine receptors, anticholinergic activity does not show. The tool greatly reduces arterial pressurepossesses antiarrhythmic and cataleptogenic activity.

At intravenous the introduction manifests itself after 3-5 minutes, reaching its maximum level in half an hour. About 90% of the active substance binds to plasma proteins. Him metabolites excreted through the kidneys, in its original form - with urine and feces.

Indications for use

Droperidol is prescribed:

  • with strong psychomotor agitation and / or hallucinations;
  • before operations or instrumental studies;
  • for local anesthesiapotentiating general or local anesthesia;
  • together with Fentanyl, for achievement antipsychotic effect and analgesia, warnings shock and vomiting;
  • at post-traumatic shockafter poisoning, burnsserious injuries.

Contraindications

The drug is contraindicated:

  • at extrapyramidal disorders;
  • during caesarean section;
  • at allergies derivative or other preparations morphine;
  • if the patient is in coma;
  • in severe depression;
  • at hypokalemia or arterial hypotension;
  • if on electrocardiogram interval extended QT;
  • children under 2 years old.

Side effects

Droperidol may cause:

  • dysphoria, depressed and drowsiness (if it is used in the period after surgery);
  • possible decline HELL, tachycardia, seldom - arterial hypertension;
  • when using very large doses, a sense of fear and a strong psychomotor irritability of the central nervous system, anxiety;
  • lack of appetite, indigestionnausea
  • extrapyramidal disorders;
  • jaundice, level up liver enzymes;
  • dizziness, bronchospasm, anaphylactic shock, laryngospasm.

Instructions for use of droperidol (method and dosage)

The drug is administered intramuscularly, subcutaneously or intravenously.

The procedure is carried out strictly under the supervision of a doctor.

The dosage and method of administration depends on the goal and type of therapy.

Instructions for use of droperidol for sedation

The introduction of 2.5-5 ml of the drug with 0.1 mg is recommended. fentanyl or 1 ml of 2% solution promedola in half an hour. Additionally, enter atropine or metacin.

Endotracheal anesthesia

Introduced 2.5 mg of the drug per 5 kg of patient’s body weight + fentanyl. Then apply seduxen or hydroxybutyrate sodium. Additionally, with this form anesthesiause a mixture of gases (nitrous oxide + oxygen) If necessary, anesthetics are administered after 20-30 minutes. If arises cardiac arrhythmiaIt is recommended that an additional dose of droperidol be administered (up to 5 mg). Possible application muscle relaxants.

Local anesthesia

The drug is administered in / m or in / in. The recommended dosage is 0.1 mg per kg of patient weight. Then, after 10 minutes, you can enter a test dose fentanyl. If no reactions have occurred hypersensitivity, fentanyl introduced intravenouslyslowly every 8 minutes. Enter every half hour droperidol at a dosage of 0.09 mg per kg of patient weight.

In the period after surgery, you can use 2.5-5 mg of the drug intramuscularly in conjunction with fentanyl.

At myocardial infarction, pulmonary edema or heavy angina pectoris recommended introduction intravenously 1-2 ml droperidol and the same amount fentanyl at glucose. The mixture can also be used for stopping. hypertensive crises.

In preparation for a painful diagnosis, they are administered in / in, 30 minutes before the procedure, from 2.5 to 5 mg droperidol.

During the use of the drug, special care should be taken, remember the likelihood of drug interaction with other drugs.

Overdose

With an overdose, there will be a sharp and pronounced decrease blood pressureincreased adverse reactions.

As therapy, it is recommended to produce symptomatic therapy, apply anticholinergic drugs, analeptics, sympathomimetics. If developed hypovolemia, compensation of the volume of circulating blood should be made.

Interaction

When combined with other depressants central nervous system (benzodiazepine and its derivatives, narcotic drugs, opioidssleeping pills), effects on nervous system amplified.

Droperidol is an antagonist epinephrine, sympathomimetics and adrenomimetics.

The drug enhances the effect of antihypertensive medicines and reduces effectiveness bromocriptine, levodopa and lisuride.

Terms of sale

To purchase the drug, you need a prescription in Latin, Droperidol belongs to the group of narcotic drugs.

Storage conditions

The medicine is stored in a dry, dark place, the temperature regime is not higher than 20 degrees.

Shelf life

5 years.

Special instructions

Use the drug only in a hospital setting.

People taking the drug need a doctor's supervision.

Changes in EEG after taking Droperidol will persist for some time.

When using the product with spinal or epidural anesthesia blockage may occur intercostal nerves or sympathetic nsperipheral vasodilation, decrease blood pressuredifficulty breathing.

During depressionsick epilepsy, with impaired renal or hepatic function, the medicine is usually not prescribed.

For elderly patients, physically weak or depleted, an initial dose adjustment is required.

The patient should be transported carefully, without sudden movements or changes in body position.

If you take more than 25 mg of the drug, the probability of sudden death in patients with arrhythmia, hypoxia, alcohol withdrawal or violations electrolyte balance.

Within 24 hours after taking the drug, it is not recommended to drive a car or perform operations that require a high concentration of attention or reaction speed.

Analogs

Matches for ATX Level 4 code:Haloperidol DecanoateHaloperidol

The most common analogues of the drug: nitrous oxide, Ketamine, Medxenon, Sodium oxybutyrate, Predion, Propovan, Propofol Fresenius, Diprivan, XeMed, Pofol, Provive, Recofol.

Synonyms

Droleptan, Synodril, Inapsin, Dehydrobenzperidol, Dridol.

During pregnancy and lactation

The medicine is not recommended for use in pregnant women. However, this is possible after consultation with a specialist.

The drug is able to excrete with milk and is not recommended for use during breastfeeding. If there is an urgent need to use this tool, then feeding should be stopped.

Reviews

Droperidol has mostly good reviews. Doctors note its high efficiency and gentle effect on the nervous system, heart muscle. It is believed that the drug is indispensable for hypertensive crisis as part of complex therapy. Side effects when using the drug in a hospital environment do not occur. It is highly recommended that you do not self-medicate and do injections of the drug without specialist supervision.

Droperidol Price

On average, the cost of the drug is 130 rubles for 10 ampoules with a capacity of 2.5 ml.

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