The tablets contain the active ingredient: rabeprazole sodium.
Additional components: attracts, magnesium oxide, slightly substituted hydroxypropyl cellulose, hydroxypropyl cellulose, magnesium stearate, ethyl cellulose, hypromellose phthalate, diacetylated monoglyceride, talc, titanium dioxide, iron oxide red, carnauba wax, food grade gray ink F6.
Pariet is available in the form of enteric-coated tablets, 10 mg, 20 mg of the active substance. Tablets are packed in blisters of 7 or 14 pieces, 1-2 blisters in a pack.
Characteristic for the drug antiulceract.
Pharmacodynamics and pharmacokinetics
Rabeprazole is an antisecretory substance derived from benzimidazole. This component is characterized by suppression of gastric acid secretion during specific inhibition of H + / K + -ATPase in the secretory surface of parietal gastrointestinal cells. In this case, the H + / K + -ATPase is a protein complex that functions as a proton pump. Therefore, we can say that rabeprazole sodium - It is a proton pump inhibitor in the stomach, blocking the final stage of acid production. This effect is considered dose-dependent and causes suppression of basal and stimulated acid production, regardless of the stimulus. For rabeprazole sodium anticholinergic properties are not characteristic.
Absorption rabeprazole from the digestive tract occurs quite quickly. Therefore, the achievement of the maximum concentration of the substance is noted already after 3.5 hours with a dose of 20 mg. Moreover, the absolute bioavailability is approximately 52%. Repeated administration of the drug does not affect the change in bioavailability.
In the human body rabeprazole binds to plasma proteins by 97%. Main part rabeprazole excreted in the urine, mainly in the form of metabolites: carboxylic acid and mercapturic conjugate and other substances. Excretion of the remainder of the drug occurs with feces and bile.
Indications for use
Indications for Pariet in different dosages are slightly different. Therefore, 10 mg tablets are prescribed for:
dyspepsia caused by high acidity of gastric juice, accompanied by heartburn and sour burp.
The drug 20 mg is recommended for use with:
- peptic ulcer of the stomach, duodenum 12 with exacerbations;
- erosive and peptic ulcer gastroesophageal reflux disease and reflux esophagitis;
- non-erosive gastroesophageal reflux disease;
- maintenance treatment of gastroesophageal reflux disease;
- Zollinger-Ellison syndrome and conditions associated with pathological hypersecretion;
- eradication Helicobacter pylorifor patients ulcerative lesions.
The medicine is not prescribed for:
- hypersensitivityto rabeprazole;
- lactation, pregnancy;
- up to 12 years old - 10 mg drug, up to 18 years old - 20 mg.
As clinical practice shows, in most cases, patients tolerate this medicine well. If side effects occur, then usually they are weak and pass quickly, for example: headache, flatulence, stomach ache, constipationdry mouth dizzinessrash peripheral edemaand so on.
Pariet tablets, instructions for use (method and dosage)
This medicine is intended for oral administration, as a whole. It is noted that the activity of the main component is not affected by the time of ingestion or eating food.
According to the instructions for use of Parieta 10 mg, it is prescribed for taking a tablet once a day, preferably in the morning before meals, as this increases the effectiveness of treatment.
Tablets of 20 mg are prescribed for complicated diseases of the gastrointestinal tract, so how to take them for various disorders, the specialist indicates. In addition, with various diseases, not only a certain dosage and treatment regimen is established, but also its duration. Therefore, you should not take this drug on your own.
Cases of overdose in clinical practice have not been noted, but they should not be completely ruled out. It is assumed that taking high doses of the drug may increase the severity of side effects. Treatment is carried out depending on the symptoms.
As a rule, taking this drug with other drugs does not lead to significant drug interactions. However for rabeprazole sodium persistent and prolonged suppression of the production of gastric juice is characteristic. In this case, interaction with components whose absorption is pH dependent is possible.
Combination with ketoconazole reduces its absorption by 30%, while digoxin increases by 22%. For this reason, dosage adjustment is necessary in the direction of decreasing or increasing.
Simultaneous reception rabeprazole sodium with fatty foods often slows down its absorption for 4 or more hours, without affecting its concentration in the body. Combinations with methotrexate, especially at higher dosages increases its concentration or metabolite - hydroxymethotrexate almost 2 times.
Terms of sale
10 mg tablets are dispensed without a prescription.
Parit 20 mg can be purchased with a doctor’s prescription.
Storage of the drug requires a dry, cool and dark place inaccessible to children.
Analogs of ParietMatches for ATX Level 4 code:HairabesolNofluxLantsidBarolBeretOntimeGastrozoleOmeprazolePantoprazoleProxyLansoprazoleZulbeksUltopEpicurusLosek MapsLosekSunprazEmaneraOmez InstaOmez
Analogs of Pariet are presented by drugs: Rabeprazole, Omeprazole, Ranitidine, Famotidine, Nexium and others.
Which is better - Parry or Nexium?
Patients are often interested in whether they should take this drug or choose Nexium? In any case, the appointment of each of the drugs is performed individually and is directly dependent on the complexity of the disorder, laboratory parameters and patient characteristics.
However, many experts are sure that Pariet has greater effectiveness, faster action, which requires a small dose, and less manifestation of side effects. As for the cost, both drugs are not cheap, which justifies their effectiveness.
There is no direct contraindication to drinking alcohol when taking these tablets. However, the indications for which treatment is prescribed by Pariet recommend not drinking alcohol.
Reviews about Pariet
In most cases, reviews about Pariet are related to its effectiveness. As you know, it is prescribed for treatment gastritis, ulcers, heartburn and so on. It is reported that even when acidity decreases temporarily, it already helps in restoring the health of the digestive tract.
However, reviews received by Pariet are not always positive. There are stories that treatment with this drug did not bring the expected results - pain and heartburn persist. According to experts, this can indicate both an incorrect diagnosis and an inappropriately prescribed therapeutic regimen. Therefore, patients should not continue to suffer from unwanted symptoms, but should consult a specialist.
In addition, for Pariet, as well as other drugs for the treatment of the gastrointestinal tract, selective efficiency is characteristic, which manifests itself differently for various disorders. This means that it can be taken only with an accurate diagnosis.
Pariet price, where to buy
Pariet prices in Moscow and pharmacies in other regions are not particularly different. Therefore, you can buy 10 mg Pariet in Moscow for 790-1200 rubles, depending on the number of tablets in a pack
The price of Pariet 20 mg is from 1300 rubles.
- Online Pharmacies in Russia
- Online pharmacies in UkraineUkraine
- Online pharmacies in Kazakhstan
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