Medication

Cyanocobalamin

Structure

Vitamin B12, water for injection, sodium chloride.

Release form of cyanocobalamin

Solution for injection at a concentration of 0.02%, 0.05% in ampoules of 1 ml, packaging - in cardboard packaging No. 10.

Pharmachologic effect

Cyanocobalamin is a biologically active drug that has hematopoietic, erythropotic, metabolic and antianemicact. Accelerates the healing processes of tissues, normalizes the central nervous system and the hematopoietic system, improves liver processes, enhances activity thromboplast and prothrombin, activates the blood coagulation process, reduces the amount of cholesterol in blood.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Activates the exchange proteins, fats and carbohydrates. It forms an energy reserve in the body and is actively involved in the process of transmission of nerve impulses. Included in phosphocreatineand contributes to the accumulation hemoglobin at red blood cells. Stimulates bone marrow (normoblastic erythropoiesis). This drug normalizes liver function, positively affects the blood coagulation system, in high doses increases activity prothrombin.

Pharmacokinetics

The drug is absorbed mainly in the small (less in the large) intestine, then it is transported through the receptor system into the cell. In the blood it binds to transcobalamin I and II, and then is transported to tissues, where it is metabolized. In the body, this vitamin is deposited in the liver. It is excreted from the body by the renal excretory system.

Indications for use of the drug

  • iron deficiency anemia various genesis;
  • folic acid deficiency and vitamin deficiency anemia;
  • cirrhosis of the liver;
  • dystrophy in young children;
  • motor neuron disease;
  • lumbosacral radiculitis;
  • cerebral paralysis in children;
  • lesions of the trigeminal nerve;
  • scattered sclerosis;
  • polyneuropathy;
  • chronic hepatitis;
  • Down syndrome;
  • neuralgia, neuritis;
  • skin diseases (psoriasis, eczema).

Contraindications

Angina pectoris, thromboembolism, erythremia(Wakez disease) erythrocytosis(increased red blood cell count).

Side effects

Mental agitation tachycardia, allergic reactions, dizziness, headache, diarrhea.

Instructions for use of cyanocobalamin (method and dosage)

Injected drug intramuscularly, intravenously, subcutaneously and intralumbal. Cyanocobalamin therapy is accompanied by regular monitoring of coagulation parameters and the general picture of blood. Doses of the drug depend on the specific disease:

  • at aplastic anemia 100 μg are administered every other day until hematologic and clinical improvement is obtained;
  • at iron deficiency and posthemorrhagic anemia - 30-100 mcg three times a week;
  • anemia in children - 40 mcg per day for 15 days;
  • neurological traumatic diseases and nervous system diseases - in increasing doses from 250 to 500 mcg, the duration of treatment is up to 2 weeks; with the improvement of the patient's condition - 100 mcg per day;
  • peripheral nerve damagecaused by trauma - 200-400 mcg every other day for a month and a half;
  • Down diseasecerebral palsy and dystrophy in children - 15-30 mcg per day;
  • diabetic neuropathy, radiation sickness- 60-100 mcg for a month.
  • hepatitis and cirrhosis of the liver - 100 mcg per day for 30 days;
  • funicular myelosis, multiple sclerosis - 15-30 micrograms of solution are administered, increasing the dose gradually from 200 to 500 micrograms.

Overdose

Possible development: pulmonary edema, peripheral vascular thrombosis, urticarialess commonly anaphylactic shock.

Interaction

Cyanocobalamin is such vitaminwhich is incompatible with thiamine bromide, riboflavin and pyridoxine (in one syringe). With simultaneous appointment with antibiotics (kanamycin, polymyxins, neomycin and tetracyclines) the absorption of this drug is difficult. Do not take together with drugs that affect blood coagulation. Therefore, if you have been prescribed cyanocobalamin, the instructions for use should be carefully studied.

Terms of sale

Prescription Leave.

Storage conditions

Cyanocobalamin (Vitamin B12) List B preparation: Storage temperature 2 - 20 ° C in a darkened place.

Shelf life

Two years

During pregnancy

Use with caution during pregnancy due to the possible teratogenic effects of large doses of B vitamins on the fetus.

Analogs

Cyanocobalamin-Darnitsa, Cyanocobalamin-Vial, Cyanocobalamin Bufus, Medivitan.

Vitamin B12 Combination Medications

There are a number of combination drugs on the market - cyanocobalamin tablets in combination with folic acid (Russia), Nowfoods B12, Solgar Vitamin B12 (USA), Neurobion (Germany), Neurovitan (Italy). As a rule, the form of release is tablets.

Reviews on cyanocobalamin

Reviews about the drug are mostly positive. Patients note that after a course of treatment, hemoglobin rises, health and sleep improve, depression disappears, and pain with neuralgia and trigeminal inflammation decreases.

According to patients, cyanocobalamin in ampoules is an effective tool for hair. Many women are interested in how to use cyanocobalamin for hair. Like all B vitamins, it has a positive effect on the hair. Even regular (1 time per week) injections of the drug contribute to the strengthening of hair roots, reduce their loss. The drug is often used as a component of hair masks or in pure form for rubbing into the hair roots.

Price of cyanocobalamin, where to buy

You can buy the drug in all pharmacies. The price of cyanocobalamin in pharmacies in Moscow varies from 14.5 to 25.0 rubles per pack.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

ZdravCity

  • Cyanocobalamin (Vit B12) solution d / in. 0.5 mg / ml 1ml n10OAO Dalkhimpharm 32 rub.order
  • Blagomin vitamin B12 (cyanocobalamin) caps. 9mcg 0.2g n90VIS OOO171 rub.order

Pharmacy Dialog

  • Vitamin B12 (cyanocobalamin) (amp. 500mkg / 1ml No. 10) 24 rub.
  • Vitamin B12 (cyanocobalamin) (amp. 500 μg / 1ml No. 10) 27 rub.
  • Vitamin B12 (cyanocobalamin) (amp. 500mkg / 1ml No. 10) 25 rub.

Eurofarm * 4% discount on the promotional code medside11

  • Cyanocobalamin injection for injection 500 mcg / ml 1 ml n10 ampOAO "Yerevan HFF" 27 rub.order
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Pharmacy24

  • Cyanocobalamin-Darnitsa 0.02% 1 ml No. 10 solution PrAT "Pharmaceutical company" Darnitsya ", Ukraine14 UAH order
  • Cyanocobalamin 0.05% 1 ml No. 10 solution for injection PAT "Halichpharm", Ukraine 12 UAH order
  • Cyanocobalamin-Darnitsa 0.05% 1 ml No. 10 solution for injection PrAT "Pharmaceutical company" Darnitsya ", Ukraine17 UAH order

Pani Pharmacy

  • Cyanocobalamin injection 0.05% ampoules 1ml №10 Ukraine, Darnitsa PrJSC 18 UAH order
  • Cyanocobalamin injection 0.02% ampoules 1ml №10 Ukraine, Darnitsa PrJSC 16 UAH order
  • Cyanocobalamin injection 0.05% ampoules 1ml No. 10 Ukraine, Galichfarm AOOT 14 UAH order
  • Cyanocobalamin injection 0.05% ampoules 1ml №10 Ukraine, Lekhim-Kharkov CJSC 16 UAH order
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BIOSPHERE

  • Cyanocobalamin (Vitamin B_12) 500 mcg / ml No. 10 solution for in.amp. Borisov ZMP (Belarus) 250 tg.order
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