Human immunoglobulin


Immunoglobulin human normal It contains the active substance - the immunoglobulin fraction. It is initially released from human plasma, after which it is purified and concentrated. In the composition of the drug is not antibodies to human immunodeficiency viruses and hepatitis C, it does not contain antibiotics. Protein concentration is 4.5% - 5.5%. Low anticomplementary activity of the drug is noted.

Release form

Immunoglobulin preparations are available in two forms. This is a solution for intramuscular injection and dry powder for infusion (IV immunoglobulin). A solution is a clear or slightly opalescent liquid without color.

Pharmachologic effect

This medicine is having immunostimulatory and immunomodulatory act. It contains many opsonizing and neutralizing antibodies. Their presence provides an effective resistance to bacteria, viruses and several other pathogens.

Under the influence of this agent, the amount of missing IgG antibodies is compensated. As a result, the risk of developing an infection in people diagnosed with primary and secondary is reduced. immunodeficiency. Immunoglobulin fills and replaces natural antibodies in human serum.

To understand the essence of the effect on the body of this drug, it should be understood how immunoglobulin acts in the human body, what it is. Wikipedia indicates that immunoglobulins are unique immune molecules that can neutralize a number of toxins and many pathogens in the human body.

To neutralize a certain type of virus or bacteria, the body produces unique types of immunoglobulins. There is a classification according to which classes of immunoglobulins are determined depending on antigenic characteristics, properties, structure.

If necessary, a blood test is carried out for immunoglobulin, general and specific. Such an examination can determine the presence of allergic diseases and prescribe the right treatment. A specialist can decrypt the results of the analysis in detail, determining if the immunoglobulin is elevated (the norm of its content depends on the person’s age). If a certain class is raised, what does this mean, the specialist will explain in detail.

Pharmacokinetics and pharmacodynamics

During intravenous infusion bioavailability is 100%. The highest concentration of antibodies in human blood is observed for 14 days. The half-life of antibodies is 4-5 weeks. The drug penetrates the placenta, passes into breast milk.

Indications for use

Normal human immunoglobulin is indicated as a substitution treatment if the patient needs to undergo substitution treatment in order to replace and replenish natural antibodies.

In order to prevent infections, it is prescribed in the following cases:

  • when carrying out a bone marrow transplant;
  • with agammaglobulinemia;
  • in the case of primary and secondary immunodeficiency, with variable immunodeficiency;
  • at lymphocytic leukemiahaving a chronic nature;
  • at Aids in children;
  • with thrombocytopenic purpura, which is of immune origin;
  • with severe bacterial and viral infections;
  • with Kawasaki Syndrome;
  • with Guillain-Barré Syndrome;
  • with red blood cell aplasia;
  • with neutropenia, which has an autoimmune origin;
  • with chronic demyelinating polyneuropathy;
  • with hemolytic anemia and thrombocytopenia, having an autoimmune origin;
  • at hemophiliaprovoked and caused by the synthesis of antibodies to factor P;
  • in the process of treating myastenia gravis;
  • in order to prevent habitual miscarriage;
  • for the prevention of infectious diseases in premature infants.


The following contraindications for the use of this drug are determined:

  • high sensitivity to human immunoglobulins;
  • IgA deficiency due to the presence of antibodies to it;
  • allergic processes in acute form;
  • renal failure;
  • diabetes;
  • anaphylactic shock for blood products.

When prescribing the drug, not only contraindications should be considered, but also those conditions and diseases in which treatment should be carried out with caution.

Very carefully prescribed remedy for people suffering migraine, decompensated heart failure chronic in nature as well pregnant womenmothers during natural feeding. With caution and only after the appointment of a doctor, therapy is carried out for people suffering from diseases whose origin is associated with immunopathological mechanisms (collagenosis, nephritis, immune blood diseases).

Side effects

If the patient is given a normal human immunoglobulin, and the correct treatment regimen, dosage and administration features are observed, then pronounced side effects are rare. However, it should be noted that side effects can occur several hours or even days after the drug has been administered. In most cases, negative manifestations completely disappear after taking the drug has been discontinued.

In general, side effects are observed due to the too high rate of infusion of the drug. If you temporarily suspend the introduction or reduce its speed, then most of the negative effects will disappear. If the negative symptoms do not stop, symptomatic treatment is necessary.

Most often, side effects are observed when Immunoglobulin is administered to a person for the first time, moreover, it develops within the first hour. These may be the following symptoms:

  • flu-like syndrome (fever, chills, headache, weakness);
  • dry cough, dyspnea;
  • vomiting, diarrheasevere salivation; stomach pain;
  • tachycardia, cyanosis, flushing of the face, pain in the chest;
  • weakness, drowsiness, sensitivity to light, impaired consciousness, in rare cases - signs of aseptic meningitis;
  • in rare cases, acute tubular necrosis is manifested, the condition may worsen in people with renal failure;
  • allergic manifestations;
  • local reactions.

In addition to the above symptoms, there may be pain in the joints, myalgia, sweating, hiccups, backache. Loss of consciousness is very rare, collapsesevere hypertension. If the response to therapy is very serious, treatment must be canceled. If necessary, you can enter adrenalin, antihistamines, solutions that replace plasma.

Instructions for use of Immunoglobulin (Method and dosage)

The instruction for Immunoglobulin provides for the possibility of drip intravenous and intramuscular administration of the drug. As a rule, the dose of the drug is prescribed individually, taking into account the severity of the disease, condition immunity and etc.

Instructions for use of the drug for children provide for the introduction of 3-4 ml of the drug per 1 kg of the child’s weight, while the dose should not exceed 25 ml. Before administration, Immunoglobulin must be diluted with 0.9% sodium chloride solution (sterile) or 5% glucose solution, respectively 1 part of the drug and 4 parts of the solvent. It is administered drip intravenously, while the speed should be 8-10 drops per minute. Infusion is carried out within 3-5 days.

Adult patients receive a single dose of 25-50 ml. It is not necessary to dilute the drug additionally, it is administered drip intravenously, while the rate of administration is 30-40 drops per minute. 3-10 transfusions are prescribed for the course of treatment, which are carried out after 24-72 hours.

If the question arises, where to put the dropper, it should be noted that the drug can be administered intravenously only in a hospital, while it is important to strictly observe the requirements of asepsis. Where you can get an immunoglobulin injection, you can find out at your nearest medical facility. You can also get information on under what conditions Immunoglobulin is administered to children for free.

Before introducing the product, the bottle must be kept at least 18 hours at a temperature of 18 to 22 ° C. If the solution is cloudy or there is a precipitate in it, you can not enter it.


Perhaps the manifestation of signs of an overdose of the drug when administered intravenously. These symptoms are hypervolemia and high blood viscosity. Overdose symptoms are more likely to occur in the elderly and in patients with kidney disease.


There is a pharmaceutical incompatibility of the drug with other medicines. It can not be mixed with other drugs, you should always use a separate dropper for Immunoglobulin.

The effectiveness of the drug may decrease if it is administered at the same time as immunization medications. rubellaat chickenpoxat measles.

If there is a need to use parenterally living viral vaccines with chickenpox, etc., they can be used 1 month after treatment with Immunoglobulin, but it is advisable to withstand a break of 3 months.

Do not use the drug at the same time calcium gluconate in the treatment of infants.

Terms of sale

In pharmacy chains, it is sold by prescription.

Storage conditions

It is necessary to transport and store the drug, respectively, with SP, the temperature regime is 2-8 ° C. Do not freeze.

Shelf life

Shelf life 1 year. Do not apply after this period.

Special instructions

Patients who are diagnosed with diseases whose origin is associated with immunological mechanisms, you can use Immunoglobulin only after consulting a doctor who is involved in the treatment of such diseases.

The introduction of the drug must be recorded in the appropriate accounting form, in which you need to indicate the series, number, date of manufacture, expiration date, date of administration, dosage and reaction to receiving the drug.

The use of the drug is not allowed if the container with it has been damaged. After opening the container, the medicine is used as a slice; it cannot be stored open.

The protective effect of the drug is observed after 24 hours and lasts for 30 days.

After the use of Immunoglobulin, a passive increase in the number of antibodies in the blood is noted. Therefore, when blood is given for analysis, subsequently, the decoding of a blood test for immunoglobulin may be incorrect.

Diagnosed patients allergic diseases or celebrated tendency to allergic manifestationsshould receive antihistamines on the day of the introduction of the solution and for eight days after receiving it.

After the drug has been administered to the patient, it is necessary to observe him for another half an hour. The specialist should have access to anti-shock therapy.


Matches for ATX Level 4 code:PentaglobinOctagam

In medicine, a number of analogues of this tool are used. These are drugs Gamunex, Immunovenin, Intraglobin, Pentaglobin, Intratect, Gabriglobin, Endobulin and etc.

In order to choose an adequate analogue, it should be understood what Immunoglobulin is and be sure to consult a doctor. To determine which drug will be most optimal for the treatment or prevention of diseases, for example, Immunoglobulin or Iodantipyrine for prevention tick-borne encephalitis, be sure to consult with a specialist.

For children

You can prescribe the drug to children if there are indications, while it is important to strictly adhere to the dosage described in the instructions.

With alcohol

Immunoglobulin and alcohol are incompatible, since alcohol is an immunosuppressant, it impairs the functioning of the human immune system. When drinking alcohol during treatment with this drug, the likelihood of side effects increases sharply. In addition, diseases and conditions requiring the administration of Immunoglobulin suggest a categorical ban on alcohol consumption.

Immunoglobulin during pregnancy and lactation

Information on harm in the appointment of funds for pregnant absent. However, intravenous administration or injection of Immunoglobulin during pregnancy is performed only if there are clear indications.

Discussing the effectiveness of Immunoglobulin, women leave reviews during pregnancy different, noting that the drug can alleviate the condition in many diseases, in particular with cytomegalovirus, herpes and others. When lactation the use of the medicine is practiced with caution, as it passes into breast milk and ensures the transmission of antibodies to the baby. For women after childbirth, the drug is administered if indicated.

Immunoglobulin reviews

Reviews of normal normal intramuscular and intravenous immunoglobulins indicate both the effectiveness of the drug in many diseases, and the manifestation of negative effects when using it. It is noted that after the introduction of the drug, one often feels weakness, malaise, chills.

Reviews during pregnancy are also sometimes contradictory: some women are sure that they should not even take risks. Nevertheless, experts assure that under the supervision of a doctor, such treatment is beneficial.

Immunoglobulin price, where to buy

The price of normal human immunoglobulin for intramuscular administration is 850-900 rubles. for 10 ampoules. Where to buy human immunoglobulin in Moscow, in Yekaterinburg and in other cities, where to give an injection, and how much is a human immunoglobulin, you can find out at the nearest medical institution. The price of IV immunoglobulin is an average of 2600 rubles per bottle of 25 ml. The cost of an injection (ampoule) in Russia (Moscow, Chelyabinsk, etc.) is about 100 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine

Eurofarm * 4% discount on the promotional code medside11

  • Human immunoglobulin normal solution for infusion 50 mg / ml 25 ml 1 flFGUP NPO Microgen of the Ministry of Health of the Russian Federation Nizhny 3091 rub.order
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Pani Pharmacy

  • Human immunoglobulin normal ampoule Immunoglobulin people normal. solution 1.5ml amp. No. 10 Ukraine, Biopharma Plasma LLC 1046 UAH to order
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