Medication

Prozac

Structure

One capsule contains 20 mg fluoxetine (as hydrochloride).

As auxiliary substances used starchand dimethiconeas well as the capsule shell contains dyes blue patented, cyan V and iron oxide yellow, titanium dioxide, gelatin, identification printing with food ink.

Release form

In a cardboard box there is 1 or 2 blisters with 14 capsules (20 mg) of size No. 3, hard gelatin opaque, green / cream color, have the logo “LILLY” and identification code “3105” ”, white powder is inside the capsules.

Pharmachologic effect

Antidepressant.

Pharmacodynamics and pharmacokinetics

Prozac is antidepressant. Wikipedia says its active substance is fluoxetineable to block neurotransmitter reuptake serotonin functional brain cells - neurons.

Fluoxetine almost not associated with other types of receptors. For example, he does not have an affinity for dopaminergic, adrenergic, cholinergicand histamine receptors. Rendering pronounced antidepressant effectthe drug is able to reduce anxiety, tensionremoves feeling fearboosting mood also lowers dysphoria.

After oral administration fluoxetineabsorbed in the digestive tract, binding to plasma proteins(more than 90%), is distributed evenly throughout the body. Peak concentration in blood plasma occurs 6-8 hours after the first dose, while the equilibrium concentration is established only after 2-3 weeks of the course.

Metabolism almost completely occurs before norfluoxetineand other unidentified substances. It is excreted by the kidneys, the half-life of the drug is 4-6 days, and the active metabolite of the fluoxetine substance is 4-16 days.

Indications for use

Apply when depressed various etiologies, bulimia nervosa, obsessive-compulsive disorder (obsessive thoughts and actions) premenstrual dysphoric disorders.

Contraindications

Hypersensitivity to any of the components of the drug.

Side effects

From the beginning of therapy, as well as with an increase in dose, the following may appear:

  • anxiety and irritability;
  • different kinds sleep disorders;
  • drowsiness and headache;
  • nausea, up to vomitingand diarrhea;
  • dysphagia, dyspepsia;
  • development possible anorexiawith a decrease in body weight;
  • hyponatremia, especially elderly patients;
  • convulsive seizures (seldom);
  • mydriasisblurred vision;
  • frequent urination, priapism;
  • decreased libido, delays or lack of ejaculation, orgasm, up to impotence;
  • secretion disorder ADH;
  • photosensitivity, alopecia;
  • ecchymosis;
  • allergic reactions in such manifestations as skin rash, itching, chills and fever, pain in muscles, joints.

Instructions for use Prozac (Method and dosage)

At depressedtaken orally (regardless of meals), starting with a dose of 20 mg per day, while increasing the dose in the absence of a clinical effect can only be done after a few weeks and subject to consultation with your doctor. If a dose of over 20 mg per day is prescribed, then it should be taken in 2 divided doses. When severe violations of the normal functioning of the liver or kidneys are observed, the daily dose and frequency of administration are reduced.

Instructions for Prozac at bulimia nervosa assumes a daily dose of 60 mg in 3 divided doses, as well as the maximum allowable daily dose of not more than 80 mg.

At obsessive-compulsive disorder the recommended dose is 20-60 mg per day,

At premenstrual dysphoric disorders- 20 mg per day.

Overdose

Taking overestimated doses can cause the following reactions:

  • cramps;
  • drowsiness;
  • vomiting;
  • nausea;
  • tachycardialengthening the Q-T interval or ventricular tachyarrhythmia, up to cardiac arrest;
  • delirium;
  • coma;
  • mania, fainting, stupor, pyrexia.

Minimum lethal dose fluoxetineit was a single dose of 520 mg, but no clear causal relationship was found.

Specific antidote unknown. The treatment takes place, controlling the general condition and cardiac activity, conducting general symptomatic and supportive therapy.

Interaction

Prozac is:

  • incompatible with MAO inhibitors - after the end of the intake of MAO inhibitors, a minimum of 14 days should elapse before the start of the course of Prozac, while cancellation fluoxetine allows you to take inhibitors only after 5 weeks;
  • a means that can change the concentration lithiumin blood;
  • combination with amino acid tryptophanand antiepileptic drug Phenytoin increases the risk of adverse reactions.

Terms of sale

With a prescription.

Storage conditions

In a place inaccessible to children, at a temperature of 15 to 30 ° Celsius.

Shelf life

Two years.

Special instructions

The drug affects mental activity and the ability to make decisions, so it is advisable for patients to avoid driving a car or operating machinery until the doctor has determined that the drug does not affect psychomotor.

Synonyms

Fluoxetine, Profluzak, Fluval.

With alcohol

You should not take ethanol-containing drugs or drink alcohol during treatment with Prozac.

Analogs of Prozac

Matches for ATX Level 4 code: Actaparoxetine Licked Fluxen Paroxin Surflift Asentra Elicea Fluoxetine Lenuxin Escitalopram Adepress Selectra Stimulus Citalopram Cypramil Zoloft Paroxetine Paxil Rexetin Fevarin

There are other drugs where fluoxetine is an active substance or a similar composition and, accordingly, pharmacological action - they include:

  • Deprenone
  • Portalac
  • Framex
  • Fluoxetine Lannacher
  • Deprex

Other selective reuptake inhibitors are also considered Prozac analogues. serotonin. Despite the other active substance, they have a similar effect, these are: Alaproclath, Citalopram, Paroxetine, Etoperidone, Sertraline and others.

Reviews about Prozac

Reviews about Prozac note a positive effect after taking the drug for depression, anxiety and other disorders, however, the course of treatment is quite protracted and the control of the attending physician is necessary. Whether or not to buy Prozac with a prescription is everyone’s choice, but it’s important to understand all the risks and responsibility for your decision.

Reviews of losing weight patients taking Prozac indicate its drawback - a large list of side effects and addiction, although they note its effectiveness in reducing appetite.

Prozac price, where to buy

The price of Prozac in Ukraine is 480-520 UAH.

You can buy Prozac in Moscow at a price of 470-560 rubles (14 capsules, 20 mg).

  • Online Pharmacies in Russia

ZdravCity

  • Prozac caps. 20mg n14Pateon France488 rub.order

Pharmacy Dialog

  • Prozac (caps. 20mg No. 14) 483 rub.order
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