Medication

Cordiamine

Structure

In drops and solution (1 ml) is 0.25 g niketamide. The substance is assigned the international name (INN) Rec.INN, registered by WHO - Nikethamide.

Recipe in Latin: Cordiaminum solution pro injectionibus 25%. Drops: Rp .: Cordiamini 15 ml. D. S. 20-25 drops 2-3 times a day.

Release form

Cordiamine Drops for oral administration in dropper bottles (1 pc. in a cardboard box) of dark glass of 25, 30 ml.

Transparent or yellowish solution (has a peculiar smell) for injection, they are produced in ampoules of 1 or 2 ml (in a box of 10 pcs.), the preparation is equipped with an ampoule knife.

Pharmachologic effect

CNS metabolism stimulator.

Pharmacodynamics and pharmacokinetics

Pharmacological group Cordiamine - analeptic, that is, it has a stimulating effect on the central nervous system, and mainly on such centers in the medulla oblongata as the respiratory and vasomotor centers. Reflex effects also partially excite the respiratory center due to excitation chemoreceptorson carotid glomeruli. Breathing under the action of the drug Cordiamine becomes faster and deeper (especially in the depressed state), while, in the case of the initial hypotension - arterial pressure rises.

The drug is able to facilitate the transmission of impulses between nerve cells - neurons, which increases the excitability, as well as the sensitivity of the centers to natural stimuli, for example carbon dioxide.

Cordiamine has a non-characteristic direct stimulatory effect on the heart or a vasoconstrictor effect. In large doses, it is known to be toxic and can cause clonic cramps.

Regarding pharmacokinetics, good absorption, regardless of the route of administration. The effect of the injection occurs after a few minutes, from oral administration - after 12-15 minutes. The duration of the effect varies depending on the type of administration:

  • intravenously - 1-1.5 hours;
  • intramuscularly - 2-3 hours;
  • orally - within 3-4 hours.

In the liver, the drug is converted to inactive metabolites and excreted to a greater extent by the kidneys.

Indications Cordiamine

The drug is prescribed to weaken the respiratory function of the lungs in patients with infectious diseasesin particular during convalescence(recovery), in case of poisoning with narcotic, sleeping pills or analgesic drugs, as well as in hypotonic conditions.

Indications for the use of Cordiamine as an additional tool is collapse, fainting, shockvarious etiologies, asphyxia, including in newborns.

Contraindications

Individual hypersensitivity to the constituent components of the drug, a predisposition to a variety of origin cramps, epilepsy.

Side effects

The following reactions are possible:

  • anxiety state;
  • muscle twitching, starting with the circular muscle of the mouth;
  • convulsions are usually clonic in nature, with an increase in dose, clonic-tonic type convulsions are possible;
  • redness of the integument;
  • allergic reactions, itching or hives;
  • nauseaand vomiting;
  • various violations heart rate.

Instructions for use Cordiamine (method and dosage)

Cordiamine is taken orally (tablets and drops are taken regardless of meals) or parenteral (injection). For drops of Cordiamine, the instructions for use suggest a dosage for adults - 15-40 drops at a time 2 or 3 times a day, for children - the number of drops per dose should correspond to the age of the child.

The solution is administered subcutaneously, intramuscularly or intravenously (parenterally). For adults, the dose is 1-2 ml from 1 to 3 times a day, for children (recommended subcutaneously) - from 0.1 ml to 0.75 ml, depending on age.

The maximum permissible single dose for adults is -2 ml (corresponds to 60 drops), daily-6 ml (corresponds to 180 drops). The maximum single dose of subcutaneous and intravenous administration for drug poisoning is 5 ml.

Overdose

Are possible crampstreatment - intravenous administration Eufillina.

Interaction

Drops of Cordiamine and other forms of the drug may change effects when combined with the following agents:

  • antidepressantsand other CNS stimulants - Cordiamine enhances their effect;
  • phenothiazide derivativesfunds for general anesthesia, paraaminosalicylic acid - reduce the effects of Cordiamine;
  • sleeping pills, narcotic, antiepileptic, anxiolytics and antipsychotic drugs - reduces their effect;
  • Reserpine enhances the convulsive effect of Cordiamine.

Terms of sale

On prescription.

Storage conditions

It is recommended to store in a place protected from light rays at temperatures up to 25 ° Celsius.

Shelf life

It can be stored under storage conditions for three years from the date of issue.

Special instructions

Cordiamine solution should be administered slowly, since subcutaneous and intramuscular injections are painful. To reduce soreness, you can use Novocaineby first introducing it at the site of the future injection. 1 ml is acceptable for an adult Novocaine0.5 or 1% solution, for children - according to age.

Synonyms

Niketamide, Cordimid.

Analogs

Matches for ATX Level 4 code:EtimizoleAmmonia solution
  • Ammonia
  • Armanor
  • Bemegrid

Reviews

Reviews of most people are positive, they consider it a means of effectively increasing pressure. The main consumer of drops are women 20-30 years old, leading a sedentary or sedentary lifestyle, because they are more prone to low blood pressure. Parents who are forced to normalize and maintain breathing in a child with an infectious disease often resort to Cordiamine injections.

Doctors usually use this drug when conducting resuscitationin newborns with asphyxia.

Cordiamine price, where to buy

The price of drops ranges from 130-170 rubles per 30 ml bottle.

The price of Cordiamine in ampoules (10 pcs. For 2 ml) is 520-600 rubles, (for 1 ml) - 230-280 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

ZdravCity

  • Cordiamine drops int. 30mlAO Tatkhimpharmpreparat95 RUB order

Pharmacy Dialog

  • Cordiamin (fl. 25% 30ml) 75 rub.order
  • Cordiamine (amp. 25% 1ml No. 10) 111 rub. Order
  • Cordiamin 25% ampoules 2ml №10143 rub.order
  • Cordiamin (fl. 25% 25ml) 66 rub.order
  • Cordiamine (amp. 25% 2ml №10) 96 rub. Order

Eurofarm * 4% discount on the promotional code medside11

  • Cordiamin drops 25% 25 mlTekhnopark-Center, OOO99 rub.order
  • Cordiamin drops 25% 30 ml Tula FF ... 99 rub. Order
  • Cordiamine injection 25% 2 ml n10 ampOAO "Dalkhimpharm" 120 rub. Order
  • Cordiamine injection 25% 1 ml 10 pcs. ampEllara OOO140 rub.order
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Pharmacy24

  • Cordiamin-Health 2 ml No. 10 solution of TOV "Pharmaceutical company" Zdorovya I ", metro Kharkiv, Ukraine42 UAH to order
  • Cordiamin-Darnitsa 2 ml No. 10 solution PrAT "Pharmaceutical company" Darnitsya ", Ukraine 50 UAH order

Pani Pharmacy

  • Kordiamin ampoule Kordiamin rr d / in. 25% amp 2ml №10 Ukraine, Health LLC 42 UAH.order
  • Kordiamin ampoule Kordiamin rr d / in. 25% amp 2ml №10 Ukraine, Darnitsa PrJSC 54 UAH order
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BIOSPHERE

  • Cordiamin 25% / 2 ml No. 10 solution for in.amp.Health - pharmaceutical company (Ukraine) 520 tg.order
  • Cordiamin 25% / 2 ml No. 10 solution for in. amp. Darnitsa (Ukraine) 720 tg.order
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