Medication

Human immunoglobulin tetanus tetanus

Structure

The solution contains tetanus antibodies with a specific effect, as additional components - glycine, sodium chloride, water for injection. The level of protein concentration is 10-16%. The concentration of antibodies to tetanus toxin is not less than 50 ME / ml. Antibiotics and preservatives are not contained in the solution.

Release form

Human immunoglobulin tetanus tetanus It is produced in the form of a solution for intramuscular injection, it is packaged in ampoules.

Pharmachologic effect

The drug Immunoglobulin tetanus tetanus is a solution of the immunologically active protein fraction that is isolated from donor plasma using ethanol fractionation method at temperatures below 0 ° C. Donors have been immunized tetanus toxoidtested for lack of antibodies to HIV and hepatitis C, as well as hepatitis B virus antigen. The drug has the ability to neutralize tetanus toxin and provides an immune defense against tetanus.

Pharmacokinetics and pharmacodynamics

The highest concentration of antibodies in the blood is observed 24 hours after the introduction of the solution. The half-life of antibodies is three to four weeks.

Indications for use

Human immunoglobulin tetanus is prescribed to provide emergency prevention tetanus in children and adults who, for certain reasons, have not received a full course of tetanus toxoid, as well as with an unknown vaccination history.

Contraindications

Do not administer the drug when hypersensitivity to certain drugs, in particular blood products. Do not use the medicine for allergic diseases, a tendency to manifest allergic reactions.

Side effects

The manifestation of local reactions in the form of pain and hyperemia at the injection site is rarely possible. During the first day after administration of the drug, the patient’s body temperature may be understood, allergy manifestations may be observed, in very rare cases anaphylactic shock.

Instructions for use (Method and dosage)

Anti-tetanus immunoglobulin is administered intramuscularly, into the outer thigh or buttocks, and the dose should be at least 250 ME (1 ampoule of the drug), regardless of the patient's age. If a large area is affected or the wound has been very contaminated, it is possible to double the single dose.

Before the injection, you need to withstand the ampoule for two hours, observing the temperature regime from 18 to 22 degrees Celsius.

To avoid the formation of foam, it is necessary to use a needle with a wide clearance to fill the solution into the syringe. The solution cannot be stored in the opened ampoule.

A skin test is not required before the injection.

Overdose

Overdose information not provided.

Interaction

Human immunoglobulin tetanus tetanus not pharmaceutically compatible with other drugs.

Under the influence of the agent, the activity of exposure to live vaccines decreases.

Terms of sale

Anti-tetanus immunoglobulin is sold by prescription.

Storage conditions

Do not freeze the solution. Store and transport the drug at a temperature of 2-8 ° C.

Shelf life

Shelf life is 2 years.

Special instructions

You can not enter the drug intravenously.

At the injection site should be funds for anti-shock therapy. Within half an hour after the introduction of the solution, a person should be under the supervision of a specialist.

People who suffer from allergic diseases or have a history of serious allergic manifestations, it is necessary to take the medicine on the day of administration and 3-8 days after the injection antihistamines. Patients who suffer from immunopathological ailments can be administered only if they receive appropriate treatment at the same time.

The doctor makes all the necessary information about the introduction of the funds in the appropriate form for accounting.

If the integrity of the container with the drug has been violated, the physical properties of the drug have changed, the shelf life has expired, such a medicine cannot be administered.

For children

If there is evidence, it is assigned to children.

During pregnancy and lactation

At pregnancyas well as during lactation it is possible to use according to indications and under the strict supervision of a doctor.

Reviews

A small number of reviews on Immunoglobulin tetanus tetanus are available. The effectiveness of the preventive effect of this medication is noted.

Price, where to buy

The price of packaging of Anti-tetanus Immunoglobulin (10 ampoules) is from 11,000 rubles.

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