The composition of the drug contains rabies immunoglobulinas well as additional glycine glycocol constituents as a stabilizer, water, sodium chloride. Antibiotics does not contain in the composition. It also does not have antibodies to HIV, hepatitis C virus, HBsAg.
Anti-rabies immunoglobulin is produced as an injection. It can be transparent or slightly opalescent. The liquid is colorless or light yellow. The drug is packaged in bottles of 1, 2, 5 ml.
Immunoglobulin anti-rabies - This is a solution of concentrated purified gamma globulin fraction of serum. It is released from the blood using the method of cold extraction with ethanol. Further, the substance undergoes an ultrafiltration process, it is purified and inactivated to ensure the removal of viruses. There are specific antibodies in the drug that can neutralize the virus. rabies.
Pharmacokinetics and pharmacodynamics
The highest level of antibodies in the blood is observed 2-3 days after the drug was administered to the patient intramuscularly. The half-life of antibodies is three to four weeks.
Indications for use
An anti-rabies immunoglobulin is prescribed in combination with an anti-rabies vaccine to prevent development hydrophobia in people who have received multiple or severe bites from patients with rabies animals or those animals that are suspicious of rabies.
With repeated multiple bites of rabies or animals suspicious of rabies, the drug is not administered if, after the first bite, the patient underwent a full course of combination rabies therapy. In this case, it is only necessary to prescribe the rabies vaccine.
Given the fact that this tool is prescribed in the presence of vital signs. No contraindications to its use are determined. People withhigh sensitivity to human blood products, as well as pregnant women, immunoglobulin should be administered only in a hospital.
In some people, the first time after receiving the drug (in the first few days) may develop hyperemiaappears swelling. Perhaps an increase in body temperature to subfebrile indicators.
Very rarely expressed allergic reactions can develop: Quincke's edemamanifestations urticaria, anaphylactic shock. Therefore, after the introduction of the drug, a person must necessarily remain under the supervision of a specialist for at least thirty minutes.
Instructions for use (Method and dosage)
If a person is injured by an animal bite, the surface of the wound should be treated immediately. It is recommended to wash the wounds and treat them with alcohol or iodine solution alcohol. If necessary, the wound is treated surgically.
Next, specific therapy should be used. The vial containing the anti-rabies immunoglobulin, before administration, must be carefully checked for integrity, to determine whether it has the necessary marking on it, whether all the physical properties of the solution are preserved.
The instruction for anti-rabies immunoglobulin provides that the drug is administered in strict compliance with all aseptic and antiseptic standards. It is not necessary to conduct a skin test before administering the drug. It is advisable to introduce the medicine as soon as possible after receiving the wound, while its dose is 20 IU per 1 kg of weight of an adult or child. An accurate calculation of the dose of the drug is carried out by the doctor immediately before administration.
Most of the dose should be infiltrated around the wound and deep into the wound. The rest of the drug is administered intramuscularly.
Adults receive an injection into the gluteus maximus; for children, the drug is injected into the anterolateral thigh.
If it is necessary to administer the drug to children, especially those with multiple wounds, the rabies immunoglobulin can be diluted with 0.9% sodium chloride solution to the extent that allows for full wound infiltration. It is necessary to administer the drug no later than 7 days after the person was in contact with an animal suffering from rabies, or with a suspicion of this disease.
Combination therapy should be carried out so as to strictly adhere to a number of conditions. Initially, a patient needs to be given an anti-rabies immunoglobulin, after which, after 30 minutes, an anti-rabies vaccine needs to be administered. This sequence of administration of these drugs must be strictly observed. Immunoglobulin administration after rabies vaccine is not allowed.
Two of the above funds must be injected into different parts of the body and use different syringes.
In no case should you exceed the dosage of immunoglobulin, since if the dose is exceeded, partial suppression of antibody production is possible.
If the patient needs to provide emergency prevention tetanus, then it can be carried out only after the anti-rabies immunoglobulin is introduced and the first vaccination of the anti-rabies vaccine is carried out.
There is no data on an overdose of the drug.
You can inject an rabies immunoglobulin at the same time as emergency tetanus prophylaxis. Other drugs can be administered only after three months after the end of combination rabies therapy.
Terms of sale
The drug is intended only for medical institutions.
It is necessary to preserve and transport the product, adhering to a temperature of 2 ° to 8 ° C, you should protect the medicine from light, it should not be frozen. Keep out of reach of children.
Shelf life is 2 years.
You can not enter the immunoglobulin anti-rabies intravenously.
Use the solution immediately after opening the vial. The remaining solution cannot be used later.
Do not administer the drug after the course of administration has been started rabies vaccine.
If the patient has hypersensitivity to heterologous immunoglobulins and serums, then in the process of drug administration it is necessary to prescribe antihistamines for 1 to 10 days. It is important to carefully monitor the person. Intravenous administration is contraindicated, so it is important to make sure during the injection process that the needle does not enter the blood vessel.
Before starting treatment, you need to inform your doctor about taking any other drugs.
For children, the drug is prescribed according to indications, is administered in the dosage specified in the instructions, in the anterolateral part of the thigh.
During pregnancy and lactation
At of pregnancy The introduction of the drug in the presence of vital indications is practiced.
Reviews about this drug are rarely left. It is noted that its use as part of complex treatment makes it possible to prevent the development of a dangerous disease that causes rabies virus.
Price, where to buy
The cost of 1 bottle of immunoglobulin anti-rabies is from 1300 rubles.
- Online pharmacies in UkraineUkraine
- Anti-rabies immunoglobulin 5 ml No. 5 solution PAT "Pharmstandard-Biolik", Ukraine5331 UAH
- Rebinolin 150MO / ml 2ml No. 1 immunoglobulin antirabies solution for injection 3647 UAH
- Immunoglobulin anti-rabies ampoule Immunoglobulin anti-rabies 5ml №5 Ukraine, Pharmstandard-Biolek 5428 UAH to order