Medication

Platyphyllin

Structure

In 1 ampoule is 1 ml of a clear, colorless solution for injection, platyphyllin hydrotartrate (2 mg). As an auxiliary substance, distilled water for injection.

One tablet contains platyphyllin hydrotartrate weighing 0.005 g plus papaverine hydrochloride0.02 g. The list of excipients includes: potato starch, calcium stearate, sugar, talc.

Release form

A cardboard box contains 5, 10 ampoules.

A combination agent with papaverine is available in the form of white tablets - 10 pcs. in blister mesh packaging.

Pharmachologic effect

The drug has a sedative, antispasmodic, vasodilating (vasodilating) effect.

Pharmacodynamics and pharmacokinetics

Flatyphylline is an international name (INN) that has been accepted for use in the UK (BAN). Platyphyllin is a pyrrolisidine alkaloid, which is found in plants of the genus Crusader (Senécio). The active substance of the drug is used as hydrotartrateLatin recipe for substance Platyphyllini hydrotartratisable to oppress cholinergic system, which transfers excitation from parasympathetic nerves to the organs-performers, thereby exerting a calming effect on the vasomotor center, blocks significantly weaker N-cholinergic receptors vegetative ganglia.

The drug has anticholinergic dose-dependent effectthat is, smaller doses inhibit the secretion of salivary and bronchial glands, sweating, accommodation of the eyes, causing pupil dilatation, increased heart rate, while large doses reduce the contractile activity of the digestive tract, including the biliary tract and gall bladder, in addition - the urinary tract and inhibits gastric secretion.

As for pharmacokinetics, Platifillin can easily pass through histohematological barriersincluding blood-brain, cell and synaptic membranes. The correct dosage and administration intervals do not induce the cumulation of the drug, however, the introduction of large doses causes its accumulation in the central nervous system in significant concentrations. It is metabolized in the liver and eliminated in the kidneys and intestines.

Indications for the use of Platifillin

Used for:

  • spasms of smooth muscles of internal organs (pylorospasmintestinal renal or biliary colic);
  • at stomach ulcer and duodenum;
  • cholecystitis or cholelithiasis;
  • at acute pancreatitis or other chronic forms;
  • at bronchial asthma or laryngospasm;
  • at arterial hypertension, angina pectoris, spasms of cerebral arteries and angiotrophoneurosisas part of combination therapy.

For diagnostic purposes, platifillin is used for pupil dilationswhen researching fundus, in determining true eye refraction, acute inflammatory eye diseases, inflammation of the iris, keratitis and other eye injuries.

Contraindications

It is forbidden to use when glaucoma, coronary heart disease, thyrotoxicosis, heart, liver or kidney failure, as well as in the presence of hypersensitivity to Platifillin.

Side effects

Dry mouth and thirstdifficulty urinating or urinary retention, paresis of accommodation (ciliary muscle of the eye), central nervous system agitation, dizzinessdilated pupils, headache, cramps, photophobia, acute psychosisfrom the cardiovascular system - tachycardia. Among other things, the appearance of lung atelectasis.

The likelihood of adverse reactions increases with high doses of Platifillin.

Instructions for use of Platifillin (Method and dosage)

It is necessary to apply parenterally (subcutaneously, intramuscularly), rectally, in ophthalmology - topically.

Injections of Platifillin, instructions for use

Apply 2-4 mg 3 times a day. The maximum allowable single dose is not more than 10 mg, while the daily dose is 30 mg. The dose is determined depending on the indications, route of administration and age of the patient.

Platyphyllinum with pancreatitis appoint 1-2 ml subcutaneously for 12 hours during a period of intense pain to reduce spasm of the smooth muscle of the gland.

Platifillin tablets, instructions for use

Take orally 1 tablet 2 or 3 times a day.

Overdose

Paralytic ileus, urinary retention, accommodation paralysis, increased eye pressure, dry mucous membranes of the mouth, nose and throat, which can cause difficulty in swallowing, mydriasisuntil the iris disappears completely, tremor, cramps, hyperthermia, excitation of the central nervous system with subsequent oppression of it, as well as the respiratory and vasomotor centers.

As a treatment used forced diuresisenter inhibitors holistenasessuch as Physostigmine, Galantamine or Prozerinthat can weaken intestinal paresis and reduce tachycardia.

In cases of moderate arousal and seizures of weak strength, it is best to administer Magnesium sulfatehowever, in severe cases - sodium oxybutyratecarry out oxygen therapyand mechanical ventilation.

If tachycardia threatens the life of the patient, then apply quinidine sulfate, Propranolol.

Interaction

Indications for the use of Platifillin should take into account the presence of diseases that require the regular use of other medical devices. With simultaneous use with the following substances, reactions may occur:

  • Haloperidol - in patients with schizophrenia antipsychotic effect may decrease.
  • Prozerin - Platifillin is its antagonist.
  • Phenobarbital, etaminal sodium, magnesium sulfate - an increase in the duration of sleeping pills.
  • Other m-anticholinergics and drugs with m-anticholinergic activity (e.g. Amantadine, Phenothiazinetricyclic antidepressants, some antihistamines) - an increase in the likelihood of adverse reactions.
  • Morphine- strengthening the inhibitory effect of Platifillin on the cardiovascular system.
  • MAO inhibitors - positive chronotropic (increased heart rate) and batmotropic effect (increased excitability of the heart).
  • Cardiac Glycosides - positive batmotropic effect.
  • Analgesics, sedatives and anxiolytics are able to enhance the action of Platifillin for pain, as a result of a smooth muscle spasm.
  • Antihypertensives / sedatives enhance the action of Platifillin with vascular spasms.

Terms of sale

A solution of Platifillin and tablets of Platifillin with papaverine are prescription.

Storage conditions

In a place protected from light rays, preferably in tightly closed original packaging, at a temperature of not more than 30 ° Celsius.

Shelf life

Ampoules can be stored in intact packaging for five years, tablets for three years.

Special instructions

It is recommended to refrain from hazardous activities, such as driving vehicles and controlling other mechanisms that require a high speed of psychomotor reactions and increased attention.

For children

It is recommended to use with caution if in children chronic lung diseases, since a decrease in bronchial secretion can cause a thickening of the secretion and the formation of plugs in the bronchi.

Children with brain injuries are at risk (the drug may enhance the effects of the disease), in addition, children with Down syndrome(there is a chance of unusual dilated pupils and increased heart rate), cerebral palsy (more pronounced reaction to anticholinergic effects). It is not recommended to give Platifillin injections to children under 15 years of age.

During pregnancy and lactation

Safety Information for the Use of Platifillin in of pregnancy or during lactation (breastfeeding) is currently absent. It must be borne in mind that the expected benefit to the mother should significantly exceed the possible risks to the fetus or child.

Analogs

Matches for ATX Level 4 code:DisflatilAprofenSpasmolCuplatonEspumisanEspumisan BabyEspumisan LEspumisan 40No-spaDrotaverine HydrochlorideBobotikDill waterPepsan-RSub SimplexSpasmomenMeverinMetacinNiaspamInfacolPapaverine
  • Meteospasmil;
  • Vinboron;
  • Infacol.

Reviews about Platyphylline

Reviews confirm the effectiveness of the drug, but the application requires great care, because Platifillin affects smooth muscles, the tension and relaxation of which a person can not control - just feel the effects of its atony or increased tone. It is necessary to supervise a competent specialist who can correctly regulate interference in this area without causing great harm to health.

Platifillin's price, where to buy

Price ampoules (for 10 pieces in a box) an average of 50 rubles., price tablets of platifillin with papaverine slightly higher - 140-180 rubles. (the package contains 10 tablets).

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

ZdravCity

  • Platifillina hydrotartrate solution s / c 2mg / ml 1ml No. 10 DalchimpharmOAO Dalkhimfarm79 rub.order

Pharmacy Dialog

  • Platifillin with papaverine (tab. No. 10) 123 rub.order
  • Platifillina g / t (amp. 0.2% 1ml №10 (5x2)) 74 rub. Order
  • Platifillina g / t (amp. 0.2% 1ml №10) 70 rub. Order

Eurofarm * 4% discount on the promotional code medside11

  • Platifillin solution for subcutaneous administration of 0.2% 1 ml n10 ampOAO "Dalkhimpharm" 76 rub. Order
show more

Pharmacy24

  • Platifillin 0.2% 1 ml No. 10 solution 50 UAH order

Pani Pharmacy

  • Platifillin ampoule Platifillina g / t rr d / in. 0.2% amp 1ml №10 Ukraine, Health LLC 47 UAH order
  • Platifillin ampoule Platifillina g / t rr d / in. 0.2% amp 1ml №10 Ukraine, Darnitsa PrJSC 55 UAH order
show more

BIOSPHERE

  • Platifillina hydrotartrate 2 mg / ml No. 10 solution for sc administration in amp. Novosibkhimpharm OJSC (Russia) 710 tenge
  • Platifillina hydrotartrate 0.2% / ml No. 10 solution for in. amp. Hympharm (Kazakhstan) 420 tg.
show more

Popular Posts

Category Medication, Next Article

Xalatan
Medication

Xalatan

Composition 50 ml of the active substance latanoprost is contained in 1 ml of eye drops. Auxiliary components are: chloride, sodium hydrogen phosphate and dihydrogen phosphate, benzalkonium chloride, as well as injection water. Release form Available in the form of eye drops in a special bottle. Pharmacological action Remedy for glaucoma.
Read More
Capsicum
Medication

Capsicum

Composition Capsicam ointment includes dimethyl sulfoxide, racemic camphor, benzyl nicotinate, turpentine oil, vanillylnonamide. Additional components: cetostearyl alcohol emulsifier type A, polysorbate 80, water, sodium cetyl stearyl sulfate, bronopol. Release form Ointment is Packed in tubes of 30 and 50 g.
Read More
Chondroxide Maximum
Medication

Chondroxide Maximum

Composition In 1 gr. cream contains 80 mg of glucosamine. In the form of auxiliary substances: dimethyl sulfoxide, peppermint oil, cetyl alcohol, polyethylene glycol, ascorbic acid, distilled water, triglycerides, curcumin. Release form Cream for external use, yellow, has a slight smell of menthol.
Read More
Vitrum Memori
Medication

Vitrum Memori

The composition of the leaves of Ginkgo bilobate extract - 60 mg in 1 tab .; additional substances - microcrystalline cellulose, calcium hydrogen phosphate dihydrate, magnesium stearate, stearic acid, silicon dioxide. Release form Tablets in a film coating, in blisters of 30 pcs. Pharmacological action Improves blood circulation in the brain, increases the flow of glucose and oxygen into the brain, regulates cellular metabolism, improves microcirculation and blood flow, improves blood vessels by expanding arterioles and increasing venous wall tone.
Read More