Medication

Finlepsin

Structure

The tablets contain the active ingredient: carbamazepine - 200 mg.

Additional components: MCC, gelatin, croscarmellose sodium, magnesium stearate.

Release form

Finlepsin is available in the form of tablets, packaged in blisters of 10 pieces, 3, 4 or 5 blisters in a pack.

Pharmachologic effect

Finlepsin tablets possess antiepileptic, antipsychotic and analgesicaction.

Pharmacodynamics and pharmacokinetics

For this antiepilepticderivative dibenzazepineis also characteristic antidepressant, antipsychotic, antidiuretic and analgesicEffect. The action of the drug is related to blockade. voltage-gated sodium channels, contributing to the stabilization of membranes of overexcited neurons, lowering synaptic conduction of impulses and inhibition of serial discharges of neurons. The release of a neurotransmitter amino acid is reduced - glutamatepossessing an exciting effect, which helps to reduce the convulsive threshold of the nervous system, and, consequently, the likelihood of an epileptic seizure.

The effectiveness of the drug is manifested in simple or complex epileptic seizures, which may be accompanied by a secondary generalization and so on. At the same time, a decrease in symptoms was noted. anxiety, depression, irritabilityand aggressiveness.

This drug is characterized by a slow, but full absorptionindependent of food intake. The concentration of the substance in the body is achieved within 12 hours with a single application Finlepsin Retard 400 mg, while maintaining therapeutic efficacy for 4-5 hours. At the same time, equilibrium concentrations of the active substance in the plasma are reached after a therapeutic course of 1-2 weeks. However, this may depend on the characteristics of the patient’s metabolism: auto-induction of enzyme systems in the liver, hetero-induction by other drugs taken simultaneously, the patient’s condition, dosage and duration of treatment. It was found that carbamazepine passes into breast milk and through the placental barrier.

The drug metabolism occurs in the liver with the formation of the main metabolites: carbamazepine-10,11-epoxide - active and inactive conjugate with glucuronic acid. As a result of the metabolic process, a less active metabolite of 9-hydroxymethyl-10-carbamoylacridane is formed, capable of inducing its own metabolism. Excretion of the drug is mainly carried out in the composition of urine, partly with feces.

Indications Finlepsin

The main indications for the use of Finlepsin:

  • various forms epilepsy;
  • neuralgia;
  • pain in nervous disorders in patients with diabetes mellitus;
  • different types of convulsive conditions - cramps, seizures, and so on;
  • alcohol withdrawal syndrome;
  • psychotic disorders.

Contraindications

Finlepsin is not prescribed for:

  • hypersensitivity to its components or tricyclic antidepressants;
  • violations of bone marrow hematopoiesis;
  • acute intermittent porphyria;
  • AV blockade;
  • concomitant use of lithium preparations or MAO inhibitors.

Caution is advised in the treatment of patients with decompensated chronic heart failure, dilution hyponatremia, liver and kidney disorders, the elderly, active alcoholism, suppression of bone marrow hematopoiesis, while taking certain medications, prostate hyperplasia, increased intraocular pressure, and so on.

Side effects of finlepsin

As a rule, side effects during treatment with this drug may develop due to excess dosages or significant fluctuations in the concentration of the active substance in the body. In most cases, the occurrence of deviations in the functioning of the nervous system is noted: dizziness, ataxia, drowsiness, general weakness, headache and so on. Manifestation is also possible. allergic reactions, eg, urticaria, erythrodermaskin rashes and other symptoms.

The hematopoietic and blood system can respond by: leukopenia, thrombocytopenia, eosinophilia, leukocytosis, lymphadenopathy. The likelihood of deviations in the digestive tract remains: nausea, vomiting, dry mouth, increase the activity of gamma-glutamyl transferase, activity and hepatic transaminases, diarrhea or constipation.

In addition, disorders associated with the endocrine system and metabolism may occur: swelling, fluid retention, weight gain, vomiting, hyponatremia etc. The development of deviations in the functions of the cardiovascular and urogenital systems, the musculoskeletal system and sensory organs should not be ruled out.

Finlepsin tablets, instructions for use (method and dosage)

This medicine is intended for oral administration, regardless of the use of food.

In the treatment epilepsy tablets are prescribed as monotherapy. If Finlepsin is attached to antiepileptic therapy, then this is done gradually, strictly controlling the dosage. In cases where the pill is skipped, it must be taken immediately, as there is an omission, but you should not replenish the pass with a double dose.

According to the instructions for use Finlepsin Retard, adult patients are prescribed a daily dose of 200-400 mg at the beginning of treatment. Then, a gradual increase in dosage is possible, allowing to achieve optimal effectiveness. The maintenance daily dose is - 800-1200 mg, while this amount is divided into 1-3 doses. The maximum allowable daily dose should not exceed 1.6-2 g.

For children, the dose of the drug depends on age. In addition, when it is difficult for a child to take a whole pill, it can be chewed, crushed and dissolved in a small volume of liquid.

Children 1-5 years old are prescribed 100-200 mg, gradually the daily dosage is increased to achieve optimal action.

Children 6-10 years old are recommended to start treatment with a daily dosage Finlepsin Retard 200 mg, then the dose is also gradually increased.

The initial daily dosage for children 11-15 years old is 100-300 mg. After which it is gradually increased by 100 mg until the optimal effect is manifested.

Average maintenance daily doses: for small patients 1-5 years old - 200-400 mg, 6-10 years old within 400-600 mg, 11-15 years old - 600-1000 mg, which are divided into several doses.

The duration of treatment is directly dependent on the indications and individual characteristics of the patient. In any case, all decisions related to therapy remain the responsibility of the physician. Usually, the issue of reducing the dose or discontinuing the drug is discussed when the patient has no seizures for 2-3 years.

Discontinuation of treatment involves a gradual dose reduction, lasting 1-2 years, under regular monitoring of EEG. In this case, children must take into account the increasing weight and age.

During the treatment of other disorders according to indications, the dosage and duration of admission are determined by the doctor, taking into account the complexity of the disease and the particular patient.

Overdose

With an overdose of Finlepsin, various symptoms may develop, indicating a violation of the nervous, cardiovascular and respiratory systems, sensory organs and general deviations.

This is manifested: oppression of the central nervous system, disorientation, drowsiness, agitation, hallucinations, coma, blurred vision, tachycardiafailure of blood pressure, fainting, respiratory failure, pulmonary edema, nausea, vomiting, urinary retention, and so on.

It has been established that there is no antidote for the treatment of overdose, therefore, supportive treatment is carried out depending on the symptoms manifested, in difficult cases - in a hospital setting.

Interaction

The combination of this drug with CYP3A4 inhibitors causes an increase in concentration carbamazepine in the composition of blood plasma and the development of adverse reactions. Combination with inducers of CYP3A4 often speeds up metabolism carbamazepine, reducing its concentration and therapeutic effect.

Simultaneous use verapamil, diltiazem, felodipine, dextropropoxyphene, viloxazine, fluoxetine, fluvoxamine, cimetidine, acetazolamide, danazole, desipramine, nicotinamide, as well as macrolides - erythromycin, josamycin, clarithromycin, troleandomycin, some azoles - itraconazole, ketoconazole and fluconazole can significantly increase concentration carbamazepinebut. The same action is characteristic of terfenadine, loratadine, isoniazid, propoxyphenegrapefruit juice, viral protease inhibitors. In this case, dosage adjustment and control of the concentration of the substance in the plasma are necessary.

A combination may result in a mutual decrease or increase in concentration. felbamate and carbamazepine.

Lower concentration carbamazepine may also: phenobarbital, primidone, metsuximide, phenytoin, fensuximide, theophylline, cisplatin, doxorubicin, rifampicin, clonazepam, valproic acid, valpromide, oxcarbazepine and a number of herbal preparations that contain Hypericum perforatum.

Carbamazepine reduces the plasma concentration of drugs such as: clobazam, clonazepam, ethosuximide, primidone, digoxin, valproic acid, alprazolam, cyclosporine, tetracycline, haloperidol,oral preparations containing estrogen and progesterone and so on.

Determined that tetracyclines weaken the healing effect carbamazepine. Use with paracetamol increases the risk of toxic effects on the liver, reducing therapeutic efficacy. Combination with phenothiazines, pimozide, molindone, clozapine, haloperidol, thioxanthenes, maprotilineand tricyclic antidepressants enhances the inhibitory effect on the nervous system, weakening the anticonvulsant effect of the drug.

Therefore, when Finlepsin is prescribed to patients, it is necessary to immediately inform the doctor about which drugs they are still taking.

Terms of sale

Finlepsin is strictly prescription.

Storage conditions

Storage of tablets requires a dark, cool place, protected from children.

Shelf life

3 years.

Finlepsin analogs

Matches for ATX Level 4 code:TegretolCarbamazepine

The main analogues of Finlepsin are represented by drugs: Actinval, Apo-Carbamazepine, Zagretol, Zeptol, Carbalepsin retard, Carbamazepine, Mazepin, Stazepin, Storilat, Tegretoland others.

Alcohol

Determined that carbamazepinereduces ethanol tolerance. But also drinking alcohol during diseases in which this drug is indicated, we can expect the development of side effects and various complications.

Reviews for Finlepsin

In most cases, users leave feedback about Finlepsin Retardwhich they or their loved ones take for several years. Some patients suffering epilepsy, note that taking this drug undesirably affects their intellectual activity, leading to the development of apathy and impaired social communication. Nevertheless, in spite of these symptoms, patients confirm the high effectiveness of the drug, allowing you to forget about the attacks.

There are reviews when Finlepsin was used in the treatment of panic attacks associated with a fear of open or, conversely, closed spaces. As a result of treatment, in most cases the panic disappears, however, some instability in the gait continues to worry.

Thus, Finlepsin is one of the most common anticonvulsant and antiepileptic drugs that has been successfully used in clinical practice. According to experts, treatment with this particular tool allows you to achieve incredible results. The main thing is to strictly comply with all doctor's prescriptions, regarding the dosage of the drug and lifestyle changes, to know exactly why Finlepsin tablets and take them only according to indications.

Finlepsin price, where to buy

Finlepsin tablets price in different regions of Russia differs slightly. In this case, you can buy Finlepsin 200 mg in 50 pieces for 215-270 rubles. Price Finlepsin Retard (400 mg, etc.) varies from 260-330 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

ZdravCity

  • Finlepsin Retard Tab. 200mg n50Teva Operations Poland Sp.z. oo 185 rubles to order
  • Finlepsin Retard Tab. 400mg n50 Teva Operations Poland Sp.z. oo 257 rubles to order

Pharmacy Dialog

  • Finlepsin retard tablets 200mg No. 50194 rub. Order
  • Finlepsin retard tablets 400mg No. 50,284 rub. Order
  • Finlepsin tablets 200mg №50230 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Finlepsin Retard 200 mg n50 tablet Teva Operations Poland Sp.z.oz.o.213 rub.order
  • Finlepsin Retard 400 mg n50 tablet Teva Pharm.Enterprise / Teva Operations Poland313 rub.order
  • Finlepsin 200 mg n50 tablet Teva Pharmaceutical Enterprises 248 rub.
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Pharmacy24

  • Finlepsin retard 200 mg No. 50 tablets TOV Teva Operations Poland, Poland416 UAH
  • Finlepsin 200 mg No. 50 tablets TOV Teva Operations Poland, Poland370 UAH
  • Finlepsin 400 mg N50 tablets TOV Teva Operands Poland, Poland528 UAH.order

Pani Pharmacy

  • Finlepsin retard tablets Finlepsin retard tablets 200mg No. 50 Poland, Pliva Krakow 363 UAH order
  • Finlepsin tablets Finlepsin tablets 200mg No. 50 Poland, Teva Operations Poland 270 UAH order
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BIOSPHERE

  • Finlepsin 200 mg No. 50 tablet retard Teva Operations Poland Sp. z.o.o. (Poland) 3 tenge
  • Finlepsin 200 mg No. 50 tablet Teva Operations Poland Sp. z.o.o. (Poland) 3 tenge
  • Finlepsin 400 mg No. 50 tablet retard Teva Operations Poland Sp. z.o.o. (Poland) 4 tg.order
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