Medication

Euthyrox

Structure

The composition of one tablet includes the active substance: levothyroxine sodium - 25-150 md.

Additional components: corn starch, gelatin, croscarmellose sodium, magnesium stearate, lactose monohydrate.

Release form

Eutirox is available in tablets with different contents of the active substance. Tablets are packaged in blisters of 25 pieces, 2 and 4 blisters in a pack.

Pharmachologic effect

The drug has an action that can replenish thyroid hormone deficiency.

Pharmacodynamics and pharmacokinetics

Eutirox is a drug based on a synthetic levorotatory isomer thyroxine. Its use affects the growth and development of tissues, metabolic processes.

Small dosages can exhibit anabolic effects on fat and protein metabolism. Medium doses cause stimulation of growth and development, metabolic processes, normalize the need for tissue oxygen, as well as the work of the heart, blood vessels and nervous system. The development of the therapeutic effect is manifested after 7-12 days, while maintaining stability during this time and after discontinuation of treatment.

Suction levothyroxine sodium occurs in the small intestine, directly in its upper section. Eating food has an effect on the absorption of the active substance, significantly reducing it. The maximum concentration of the component is reached after 5-6 hours from the time of use.

The bulk of the drug binds to serum proteins. Thyroid hormones are then metabolized, mainly in the kidneys, liver, brain and muscle tissues. Excretion of metabolites occurs with the help of the kidneys and intestines.

Indications for use

Eutirox is prescribed for:

  • hypothyroidism;
  • euthyroid goiter;
  • replacement treatment and prevention of goiter recurrence after thyroid surgery;
  • thyroid cancer;
  • diffuse toxic goiter;
  • diagnostics for testing thyroid suppression.

Contraindications

The drug is contraindicated in:

  • high sensitivityto its constituent substances;
  • untreated thyrotoxicosis, pituitary and adrenal insufficiency;
  • pregnancy in combination with antithyroid drugs.

Eutirox is not recommended for the treatment of patients with acute forms. myocardial infarction, myocarditis and pancarditis. The lactose content in the drug makes it forbidden for patients with rare hereditary diseases associated with galactose intolerance, lack of lactase or glucose-galactose malabsorption syndrome.

Precautions in use require diseases such as: coronary heart disease, arterial hypertension, diabetes mellitus, arrhythmia.

Eutirox during pregnancy and lactation

If the drug has been prescribed for treatment hypothyroidism then at of pregnancy and breastfeeding should continue. Moreover, pregnancy may require an increase in dosage due to an increase in thyroxin-binding globulin. In this case, it is important to strictly observe the dosage recommended by the doctor. It was found that taking high doses can negatively affect the development of the fetus.

Side effects of Eutirox

With the correct use of this drug, side effects practically do not occur. However, side effects such as various forms should not be ruled out. allergic reactions.

Instructions for Eutirox (method and dosage)

As the instructions for the use of Eutirox indicate, this medicine is taken orally. In this case, the daily dose is set individually, taking into account the indications and characteristics of the patient.

It is recommended to take a daily dosage in the morning, on an empty stomach. The tablet must be swallowed whole with a liquid. When hypothyroidism replacement therapy is performed, the dose is determined depending on the weight of the patients. When treating children under 3 years of age, the medicine is given before the first feeding, for half an hour. The tablet must be dissolved in water until a fine suspension is formed.

Heavy and long form hypothyroidism involves starting treatment with caution and in small doses. Then the dose is gradually increased to 25 mcg or more. In such cases, the drug is usually taken constantly, but strictly as prescribed by the attending physician.

Overdose

In case of an overdose of Eutiroks, a significant increase in the speed of metabolic processes is possible. This leads to development hyperthyroidism, and especially when exceeding the individual tolerance threshold levothyroxine sodiumas well as increasing the therapeutic dose too quickly.

In this case, overdose symptoms such as develop: arrhythmia, tachycardiaheart failure angina pectorismuscle and headache tremor, hyperemia, fever, vomiting, benign intracranial hypertension, anxiety, insomnia, hyperhidrosis, weight loss and so on.

The treatment depends on the symptoms. It is possible that the doctor will reduce the daily dose or recommend a break, prescribe beta blockers. As a result of taking excessively high doses, it is prescribed plasmapheresis. When the symptoms of an overdose are eliminated, the resumption of treatment is performed with caution, with the use of small doses.

Special instructions

Before starting thyroid hormone replacement therapy and a thyroid suppression test, you should rule out or treat diseases or abnormalities such as acute coronary insufficiency, angina pectoris, atherosclerosis, arterial hypertension, pituitary insufficiency or adrenal insufficiency.This also applies to the functional autonomy of the thyroid gland.

It is recommended to exclude the development of hyperthyroidism during treatment in patients suffering from coronary and heart failure, tachyarrhythmias. For this reason, it is necessary to regularly monitor the concentration of thyroid hormones.

If there is a suspicion of the occurrence of functional autonomy of the thyroid gland, then before treatment it is necessary to perform reactions to the introduction of thyroliberin, known as the TRH test, as well as suppressive scintigraphy.

Women during postmenopausal women diagnosed with hypothyroidism and increased risk osteoporosishigh physiological concentrations of the active component in the serum are not permissible. In this case, you need to regularly monitor the thyroid gland.

Use is contraindicated levothyroxine sodium with metabolic disorders accompanied by hyperthyroidism. Exceptions include concomitant use in the treatment of hyperthyroidism with antithyroid drugs. In the case of switching to treatment with another drug, a dose adjustment is required taking into account the therapeutic effect and laboratory data.

Interaction

The simultaneous administration of this drug with tricyclic antidepressants can enhance their effect.

Levothyroxine sodium decreases the effectiveness of cardiac glycosides.

Combination with colestyramine, colestipol, aluminum hydroxide reduces the concentration of the active substance in the plasma due to inhibited absorption in the digestive tract. Therefore, between doses of these drugs, an interval of 4-5 hours must be maintained.

The simultaneous use of Eutirox and anabolic steroids, asparaginase, tamoxifen may lead to pharmacokinetic interaction at the level of communication with plasma proteins. It was also found that protease inhibitors, namely ritonavir, lopinavir and indinavirable to affect the effectiveness of this drug. It is necessary to control the concentration of thyroid hormones and carry out timely dosage adjustment.

Combination therapy with phenytoin often increases the concentration of sodium levothyroxine, accelerating its metabolism. This drug can reduce the effectiveness of hypoglycemic agents and enhance the effect of anticoagulants.

Application with sevelamer reduces the absorption of the active substance, and tyrosine kinase inhibitors, aluminum-containing, iron-containing drugs and calcium carbonate reduce its effectiveness. When using products with soybean content, a decrease in the absorption of the active component in the digestive tract was noted.

Terms of sale

Eutirox is a prescription.

Storage conditions

Storage of medicine requires a cool, dark place inaccessible to children.

Shelf life

3 years.

Analogs

Matches for ATX Level 4 code:ThyroidinLevothyroxineThyrotomeTireocombL-thyroxine

The main analogues of the drug are presented L-thyroxine and Levothyroxine sodium. Also have a similar effect: Thyroidin and Triiodothyronine hydrochloride.

Alcohol

As you know, this drug is a natural thyroid hormone. For this reason, drinking alcohol with Eutirox is not recommended.

Eutirox and weight

Many women suffering from disorders of the thyroid gland are concerned about the question: can weight increase during treatment with Eutirox. But reviews show that the use of hormonal drugs in different ways affects both the weight of patients and their general condition. Therefore, in some women it rises, while in others it decreases.

For this reason, some believe that you can use Eutirox for weight loss, especially since once a number of hormonal drugs were really used to adjust body weight, for example, in athletes. However, experts argue that Eutiroks for weight loss, not having certain indications for this, should not be taken. Sometimes reviews for weight loss report successful cases, but usually this method of eliminating excess weight leads to serious deviations in the body.

Reviews about Eutiroks

As reviews of Eutirox show, this drug is often used in clinical practice, since thyroid disorders worry many patients.

In general, reviews on Eutirox 50 mcg report that this particular dosage is used in the treatment of most diseases. However, it is important to start therapy with small doses, for example, 12.5 μg, then increasing to 25 μg and so on. The main thing is to do it gradually.

A large number of questions arise in patients to whom the drug has been prescribed recently. Therefore, they are interested in how to take pills and Eutirox - a hormonal drug or not? Also, women are concerned about whether various side effects actually develop during treatment and can it be used for weight loss?

Often, patients who take this medicine report its good tolerance and minimal development of side effects. Of course, important conditions are: strict adherence to dosage, timely delivery of tests and lifestyle changes.

Unfortunately, there are reports in which patients report that they continue to experience severe pain, drowsiness, and depression. It is also noted that some have reduced or increased weight. In any case, all issues must be discussed with the attending physician, which will replace the treatment or adjust the dosage.

Eutiroks price, where to buy

The price of Eutirox 50 mcg for 50 pieces in pharmacies in Moscow is 130-150 rubles.

You can buy Eutirox 50 mcg in online pharmacies at a cost of 106-130 rubles.

The price of Eutirox 100 mcg varies between 117-150 rubles, and Eutirox 25 mcg can be purchased for 86-100 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan

ZdravCity

  • Eutiroks tab. 112mkg n100Merck KGaA140 rub.order
  • Eutiroks tab. 88mcg n100Merck KGaA117 rub.order
  • Eutiroks tab. 100mkg n100Merck KGaA113 rub.order
  • Eutiroks tab. 137mkg n100Merck KGaA146 rub.order
  • Eutiroks tab. 25 mcg n100Merk KGaA83 rub.order

Pharmacy Dialog

  • Eutiroks (tab. 25mkg No. 100) 99 rub.order
  • Eutiroks (tab. 150mkg No. 100) 161 rub.order
  • Eutiroks (tab. 100mkg No. 100) 130 rub.order
  • Eutiroks (tab. 137mkg No. 100) 160 rub.order
  • Eutiroks (tab. 88mkg No. 100) 127 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Eutirox 75 mcg No. 100 tabl Merck KGaA & Co., Germany132 rub.order
  • Eutirox 125 mcg n100 tabl Merck KGaA & Co., Germany177 rub.order
  • Eutirox 150 mcg No. 100 tabl Merk KGaA DE178 rub.order
  • Eutirox 25 mcg n100 tabl Merck KGaA & Co., Germany102 rub.order
  • Eutirox 112 mcg No. 100 tabl Merk KGaA171 rub.order
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Pharmacy24

  • Eutirox 25 mcg No. 100 tablets Merck KGAa, Nimechchina 107 UAH order
  • Eutirox 50 mcg No. 100 tablets Merck KGAa, Nimechchina121 UAH order

Pani Pharmacy

  • Eutirox tablets Eutirox tablets 150mkg No. 100 Germany, Merck KGaA 180 UAH order
  • Eutirox tablets Eutirox tablets 25mkg No. 100 Germany, Merck KGaA 111 UAH order
  • Eutirox tablets Eutirox tablets 50mkg No. 100 Germany, Merck KGaA 128 UAH order
  • Eutirox tablets Eutirox tablets 125mkg No. 100 Germany, Merck KGaA 175 грн. Order
  • Eutirox tablets Eutirox tablets 100mkg No. 100 Germany, Merck KGaA 149 UAH order
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BIOSPHERE

  • Eutiroks 50 mcg No. 100 tablets Merck KGaA (Germany) 1 tg.
  • Eutiroks 25 mcg No. 100 tablets Merck KGaA (Germany) 1 tg.
  • Eutiroks 125 mcg No. 100 tablets Merck KGaA (Germany) 895 tg.
  • Eutiroks 75 mcg No. 100 tablets Merck KGaA (Germany) 1 tg.
  • Eutiroks 100 mcg No. 100 tablets Merck KGaA (Germany) 1 tg.
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