Medication

Nalbufin

Structure

1 ml injection (intravenous, intramuscular) contains 20 mg or 10 mg nalbuphine hydrochloride.

Release form

The drug is made in ampoules of 10 ml. 5 or 10 ampoules per pack.

Pharmachologic effect

Pain medication.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug is analgesic opioid type. Stimulates the internal antinociceptive system mainly through opioid kappa receptors. It inhibits the interneuron transmission of pain impulses in the nervous system, changes the emotional perception of pain, stimulating the higher parts of the brain.

By analgesic effect is comparable to Morphincauses miosis, has a stimulating effect on the vomiting center, has a sedative effect, suppresses conditioned reflexes. Inhibits the center of respiration less than morfin, fentanyl or Promedol.

The analgesic effect develops rapidly and with intravenous administration occurs in 1.5-3 minutes; with intramuscular injection - after 11-15 minutes. The greatest analgesic effect can be observed after 1.5-2 hours, its duration does not exceed 6 hours.

Pharmacokinetics

Metabolism passes in the liver. The half-life is 3 hours. In its initial form, excreted in the urine (up to 70%), in the form of derivatives - with bile.

Indications for use

Strong pain syndrome (in after surgery, during gynecological operations, with heart attackwith neoplasms); premedication to inhalation anesthesia as a component of intravenous anesthesia.

Contraindications

Allergy on nalbufin.

Side effects

  • From the circulatory system: arterial hyper- or hypotension, rapid or decreased heart rate.
  • From the nervous system: dizzinessdrowsiness headache, depression, dysphoriablurred vision.
  • From the digestive system: vomiting, nausea.
  • Allergic reactions: hives.
  • Other: increased sweating.

Instructions for nalbuphine (method and dosage)

Instructions for use Nalbuphine characterizes the dosage regimen as an individual. The drug is administered intravenously, intramuscularly and subcutaneously. From 100 micrograms per kilogram of weight to 1 mg per kilogram of weight, a single dose for adults varies. For children, the initial single dose is 300 mcg per kilogram of weight. The frequency of administration is calculated depending on the clinical picture. The duration of therapy is up to 3 days.

Overdose

There are no reports of such cases.

Interaction

When combined with drugs for anesthesia, sedatives drugs sleeping pills, antidepressants, tranquilizers, antipsychotics, antihistamines means ethanolthe inhibitory effect on the nervous system is enhanced.

Terms of sale

The drug is on the prescription list. Free circulation of the drug was banned.

Storage conditions

Store in a dark place at temperatures up to 15 to 30 degrees. Keep out of the reach of children.

Shelf life

Two years.

Special instructions

As a preservative, the product contains sodium disulfitewhich can provoke in individuals with bronchial asthma (from allergies to sulfite) seizures and anaphylactic shock.

Analogs of Nalbufin

Matches for ATX Level 4 code:Butorphanol TartrateButorphanol

Analogs: Nalbufin Serb, Nalbuphine hydrochloride.

For children

Possible use in children for strict indications.

With alcohol

Alcohol exacerbates the negative effects of drugs.

In pregnancy (and lactation)

During the period of pregnancy or lactationthe drug in ampoules can only be used according to strict indications.

Reviews about Nalbufin

Reviews about Nalbuphine are found, both sharply positive and negative. However, from a severe pain syndrome, this tool does not always help effectively. And the consequences of uncontrolled administration of the drug can be deplorable, for example, the development of addiction. Therefore, it is often possible to meet discussions on the topic "how to quit Nalbufin?" or "Nalbufin, rushing or not rushing, like Morphine?".

Nalbufin's price, where to buy

To buy Nalbufin No. 10 in Moscow will cost 880-1130 rubles, for comparison, the price of Nalbufin of the same form of release in Kiev will cost an average of 326 hryvnias.

  • Online pharmacies in UkraineUkraine

Pharmacy24

  • Nalbuphine 10mg / 1ml 1ml No. 10 solution for injection 272 UAH order
  • Nalbuphine 20 mg / 1 ml 1 ml No. 5 injection for 246 UAH order
  • Nalbuphine 10 mg / ml N10 solution for injection TOV "Yuriya-Farm", Ukraine 230 UAH order

Pani Pharmacy

  • NALBUFIN ampoule Nalbufin amp. 10mg 1ml №10 Ukraine, Farmeks Group OOO 237 UAH to order
  • NALBUFIN ampoule Nalbufin solution d / in. 10mg / ml 2ml amp. No. 10 Ukraine, Yuri-Farm LLC 596 UAH to order
  • NALBUFIN ampoule Nalbufin amp. 10mg 2ml №5 Ukraine, Farmeks Group OOO 238 UAH to order
  • NALBUFIN ampoule Nalbufin solution d / in. 10mg / ml 1ml amp. No. 10 Ukraine, Yuria-Farm LLC 301 UAH order
  • NALBUFIN ampoule Nalbufin solution d / in. 20 mg / ml amp. 1ml №5 India, Rusan Pharma 281 UAH order
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