Composition Sedalgin Plus
Tablet contains 500 mg metamizole Na50 mg caffeine and 38.75 mg thiamine hydrochloride. Sedalgin Plus includes additional components: colloidal silicon dioxide 2.5 mg, wheat starch 11 mg, microcrystalline cellulose 45.75 mg, talc 12 mg, gelatin 4 mg, Mg stearate 6 mg.
Sedalgin Plus is available in tablet form. Flat, round tablets of white color with a double-sided chamfer packed in blisters of 10 pieces. Each cardboard pack has 1 or 2 blisters.
The medication has anti-inflammatory, analgesic and antipyretic effects.
Metamizole Na It has a mild anti-inflammatory effect, has an analgesic effect. The mechanism of action is based on the ability of the pyrazolone derivative to inhibit the synthesis of prostaglandins through inhibition of cyclooxygenase.
Caffeine It has a stimulating effect on the functioning of the nervous system, activating the vasomotor center, cerebral cortex and respiratory center. The active component reduces the severity of feelings of fatigue and drowsiness, increases physical and mental performance. Caffeine enhances the therapeutic effect of non-narcotic analgesic drugs, increasing their bioavailability and increasing the permeability of histohematological barriers.
Thiamine has a charity effect on neuro-reflex conductivity, improves metabolism. Also known as vitamin IN 1.
Pharmacodynamics and pharmacokinetics
The indicators depend on the components that are part of the medication.
Metamizole Na is completely absorbed from the digestive tract in a fairly short period of time. The maximum concentration indicator is recorded 1-1.5 hours after administration. The active component binds to plasma proteins and is metabolized in the hepatic system. FROM bile10% of metabolites are excreted, 90% - through the renal system. The elimination half-life is approximately 10 hours.
Caffeine is almost completely absorbed from the digestive tract. The maximum level of the active component is observed after 30-40 minutes. Caffeine is able to pass into breast milk, pass through blood-brain barrier. Metabolites are excreted unchanged through the renal system.
After ingestion, thiamine absorption reaches high numbers and is carried out in the lumen of the small intestine. Digestive enzymes thiamine hydrochloride is released from the bound state before absorption. The level of thiamine in the blood is quite low. Only free thiamine can be detected in plasma, and its phosphoric esters are found in blood cells: white blood cells and red blood cells. 40% of thiamine can be found in the internal organs, and more than 50% in the striated muscle. The phosphorylation process is carried out in the liver tissue. Thiamine diphosphate has coenzyme activity and is the most active phosphorus ester. It accumulates in the kidneys, heart muscle, liver tissue, spleen, brain. It is excreted through the renal system, part through the intestines.
Indications for use
What is Sedalgin Plus prescribed from? Mostly for stopping pain syndrome at:
- inflammatory diseases of the musculoskeletal system;
- degenerative pathology of muscle tissue;
- radicular syndrome;
- after surgery.
- individual hypersensitivity;
- expressed atherosclerotic changes;
- hepatic porphyria;
- suspected acute surgical pathology;
- intolerance to NSAIDs;
- gastrointestinal ulcer;
- sleep disturbances;
- pathological excitability;
- pathology of the hepatic system;
- bronchial asthma;
- simultaneous treatment with MAO inhibitors;
- hypertonic disease;
- kidney disease.
With caution, a combination agent is prescribed for:
- Ischemic heart disease;
- stenosis of the pyloric part of the digestive system;
- hyperplastic changes in the tissues of the prostate;
- bronchospastic reactions;
- heart failure (congestive nature);
- taking medications that inhibit the work of the nervous system;
- gastroesophageal reflux.
- thrombocytopenia (decrease in the number platelet count);
- hemolytic form of anemia;
- impaired appetite;
- increased irritability;
The cardiovascular system:
- rhythm disturbances;
- feeling of rapid heartbeat.
- itchy skin;
- anaphylactic shock;
- Quincke's edema;
If other adverse reactions appear, the patient must consult a doctor, stopping taking Sedalgin Plus.
Instructions for use (Method and dosage)
The medication is taken orally. The tablet must be washed down with water. For pain, 1 tablet three times a day is prescribed. With inefficiency, the number of tablets can be increased to 6 pieces per day. In pediatric practice, ½ tablets are prescribed three times a day, but not more than 4 pieces.
Manifested by rashes on the skin. Less often registered limb tremor, anaphylactic shock, hallucinations, a clinical picture similar to Meniere's disease. A significant excess of the recommended dosages can lead to loss of consciousness, serious changes in the heart, nervous system, and blood. Purification of the stomach and intestines from the remnants of the drug is required, the appointment sorbentscarrying out a syndromic treatment. Specific antidote for Sedalgin Plus is not developed. When diagnosing hemorrhagic gastritis gastric lavage is performed with a cold solution of NA chloride (0.9%) and antacids are administered. If necessary, oxygenation is carried out, ventilation of the lungs is supported. At epileptic seizures introduce Phenytoin, Diazepam intravenously. It is important to maintain the level of fluids and salts at the required level.
Metamizole sodium is able to enhance the toxic effect of other medicines. Medicines that increase the toxicity of Sedalgin Plus and disrupt metabolism its components:
- antidepressants (tricyclic);
- oral contraceptives.
Inducers of microsomal enzymes (Butadion, barbiturates) weaken the effect of the drug. Metamizole sodium is able to lower the level of cyclosporin in the blood. The analgesic effect of Sedalgin Plus is enhanced when taking tranquilizers and other sedatives.
Terms of sale
The manufacturer has limited storage temperature - up to 25 degrees. Limit children's access to blisters.
Overdose symptoms may also occur when the patient overuse foods high in caffeine (coffee, tea). For diseases of the kidneys and the hepatic system, an additional examination is recommended. Development risk allergic response higher in patients suffering pollinosis, bronchial asthma (atopic form). It is unacceptable to take alcohol-containing drinks at the same time as taking the medication.
AnalogsMatches for ATX Level 4 code:AntipyrineAnaldimReopyrinTempalginBenalginPentalgin ICNPentalgin NPentalginAnalginTetralginSpasmalineMaxiganSedal MPiralginBaralgin MRevalginAndipal
Reviews about Sedalgin Plus
Doctors quite often prescribe a medication as part of an analgesic therapy. On the forums, patients leave their reviews about Sedalgin Plus, indicating good tolerability of the tablets and high efficiency in the relief of pain.
Price Sedalgin Plus where to buy
The cost of packaging depends on the number of tablets and the region of sale. The price of Sedalgin Plus in Russia is 90-120 rubles for 10 tablets, and 150-200 rubles for 20 tablets.
- Online Pharmacies in Russia
- Sedalgin Plus (tab. No. 10) 150 rub.
- Sedalgin Plus (tab.№20) 228 rub.order
Eurofarm * 4% discount on the promotional code medside11
- Sedalgin plus No. 20 tab.Balkanfarma-Dupnitsa AD260 rub.order
- Sedalgin plus No. 10 tab.Balkanfarma-Dupnitsa AD170 rub.order