The package contains dragees of two types: brown (12 pcs.) And yellow (9 pcs.).
1 dragee yellow contains 2 mg valerate estradiol. 1 dragee brown contains 150 mcg levonorgestrel and 2 mg of estradiol valerate. Auxiliary components: carnauba wax, magnesium stearate, potato starch, lactose monohydrate, polyvidone, titanium dioxide, calcium carbonate, magnesium carbonate, purified water, macrogol, glucose, gelatin.
The medication is available in the form of jelly beans. Each pack of cardboard contains 1 blister with a special calendar scale (21 tablets).
Anti-menopausecontaining gestagen and estrogen. In a woman’s body, estrogen, presented in the form of estradiol valerate, is metabolized to naturally occurring 17 beta-estradiol. Thanks to the addition of levonorgestrel (gestagen) for 12 days of each cycle, it is possible to prevent the development of malignant neoplasms of the endometrium and hyperplasia. In patients suffering from irregular menstruation, while taking the medication, it stabilizes and levels out menstrual cycle (relevant for women with an unremoved uterus).
Estradiol is able to make up for the deficiency estrogen in the body of a woman upon the onset menopause and allows you to stop negative psycho-emotional manifestations, autonomic symptoms:
- hot flashes of blood to the face;
- decreased libido;
- increased sweating;
- migraine headache;
- joint pain
- sleep disturbances;
- nervous excitability;
- muscle pain;
- vaginal dryness;
- pain during intercourse.
With a lack of estrogen, bone loss is observed. Estradiol helps prevent bone destruction. The principle of exposure is based on a shift in bone remodeling (towards the formation of bone tissue) and suppression of osteoclast activity. It is proved that prolonged hormone replacement therapy can significantly reduce the risk of fractures in women with the onset of menopause. Properly selected hormonal therapy slows down the aging process, the formation of facial wrinkles, increases the level of collagen in the skin, and charitable effects on its density.
Additionally, the drug reduces the level of cholesterol, stabilize the ratio of lipid profile. It was noted that with hormonal therapy in women in the postmenopausal period, the risk of developing colon cancer.
Pharmacodynamics and pharmacokinetics
Two active substances are quickly absorbed from the digestive system. Estradiol valerate undergoes changes, metabolizing to 17-beta-estradiol and estrogen. Levonorgestrel is excreted with bile and urine in the form of specific conjugates. Estradiol is excreted in the form of metabolites in the urine by 90%. The largest portion of levonorgestrel (about 95%) comes in contact with globulin and albumin, which bind sex hormones.
Indications for use
- urogenital dystrophy(reverse form of development of the female genital organs);
- menstrual irregularities in the background menopause;
- atrophic changes in the mucous membranes and integuments (thinning, dryness);
- warning osteoporosis;
- emotional instability on the background of menopausal syndrome;
- hormone therapy after surgical removal of the ovaries;
- irritation of the urinary tract and bladder, urinary incontinence with stress during postmenopause.
- hereditary pathology of lipid metabolism;
- neoplasms of the liver tissue, severe liver disease;
- individual hypersensitivity;
- myocardial infarction;
- pathological genital bleeding, endometriosis;
- diagnosis or suspicion of the presence of hormone-dependent tumors of the mammary glands, ovaries, uterus;
- acute stage cerebrovascular accident;
- gestation pregnancy;
- diabetic angiopathy, severe diabetes mellitus;
- progressive otosclerosis, herpetic infection, itchy skinidiopathic form jaundice.
- gastrointestinal upset;
- stool disorders;
- discomfort in the epigastric region;
- change in libido;
- soreness of the mammary glands;
- chloasma (age spots on the skin), itchy skin;
- vaginal bleeding.
Instructions for Klimonorm (method and dosage)
Instructions for use of Klimonorm while preserving the menstrual cycle: start treatment on the 5th day of the cycle (the first day is considered from the moment of menstrual bleeding). With rare menstruation, amenorrhea, during menopause, the drug can be taken any day, excluding pregnancy. Packaging is designed for 21 days. Treatment begins with taking yellow tablets: 1 pc. every day for 9 days. Then take 12 brown tablets daily for 12 days. After that, they take a 7-day break during which bleeding similar to menstruation occurs. Then they start treatment again, taking pills according to the same scheme. Dragees are not designed to chew, they must be swallowed whole, washed down with water. It is recommended to take the drug every day at a specific time. If you miss more than 1 tablet, you may vaginal bleeding.
Acute adverse reactions when taking high doses of the drug have not been identified. Perhaps the development of vaginal bleeding, vomiting, nausea. Specific syndromic therapy antidote not developed.
Before treatment, all hormonal contraceptives are canceled. To prevent unwanted pregnancy, it is recommended to resort to non-hormonal contraception. Clinical effectiveness and clearance of sex hormones are reduced with the simultaneous use of hepatic enzyme inducers (antibioticsanticonvulsants). A similar effect is observed with treatment Rifampicin, Carbamazepinebarbiturates Griseofulvin. The maximum rate of enzyme induction is recorded after 2-3 weeks of therapy and can persist for 4 weeks after drug withdrawal. A drop in estradiol levels is observed when taking Tetracycline and Penicillin.
Due to the competitive inhibition of conjugation during absorption, the bioavailability of estradiol is increased against the background of simultaneous therapy with drugs that are largely conjugated (these include Paracetamol).
In patients with diabetes, glucose tolerance may change, which requires dose adjustment insulin and hypoglycemic drugs. Taking alcohol-containing drinks can increase the level of extradiol in a woman's body.
Terms of sale
You can buy a dragee in a pharmacy by presenting a medical prescription form.
Climonorm belongs to list B. The temperature regime recommended by the manufacturer is up to 25 degrees. Limit the uncontrolled access of small children to blisters with dragees.
What is better than femoston or climonorm?
When choosing a combined hormonal drug, the doctor always takes into account the age of the patient, the presence of contraindications, weight, and concomitant pathology. Therefore, it is better to rely on the opinion of your attending physician, who will take into account all the features and choose the medication that is more suitable for your body: Femoston or another combined hormonal medication.
In no case should the medication be used as contraceptive. Before treatment, a mandatory examination of the condition of the mammary glands, the liver system, cholesterol level, blood pressure. With porphyria, multiple sclerosisotosclerosis varicose veins, arterial hypertension, sickle cell anemia is an additional consultation of specialists before starting hormone therapy. With increased severity migraine headaches, in case of violation of auditory or visual perception, stagnation of bile, thromboembolic disorders, treatment is stopped.
AnalogsMatches for ATX Level 4 code:Femoston
Medicines with a similar pharmacological effect:
During pregnancy and lactation
With lactation and gestation, hormone replacement therapy is not performed. In case of accidental hormone intake in early pregnancy, no teratogenic effect was found. In women who took hormonal medications before pregnancy, there was no increase in the number of congenital anomalies in children. Data obtained from large-scale epidemiological studies on steroid hormones. Part of the medication is excreted in breast milk.
Reviews about Klimonorm (opinion of patients and doctors)
Reviews of women about Klimonorm testify to the absence of pronounced negative reactions during treatment. Patients indicate that the drug really helps to cope with unwanted psycho-emotional reactions, reduces irritability, irritability. Forums of relevant topics contain reviews of doctors who also confirm the high effectiveness of the drug in the treatment of negative symptoms of the postmenopausal period. In general, reviews about Klimonorm are positive.
Klimonorm price, where to buy
The price of Klimonorm depends on the region and varies in the range of 570-650 rubles. In Ukraine, medication can be bought for 130 UAH.
- Online Pharmacies in Russia
- Online pharmacies in UkraineUkraine
- Online pharmacies in Kazakhstan
- Klimonorm dr. N21 Bayer Weimar GmbH & Co.KG884 rub.order
- Klimonorm (dr. No. 21) 793 rub.order
- Klimonorm (other. No. 21) 861 rubles to order
Eurofarm * 4% discount on the promotional code medside11
- Klimonorm n21 drageeYenapharm GmbH & Co.KG960 rub.order
- Klimonorm No. 21 tablets Bayur Weimar GmbH i Co. KG, Nіmechchina311 UAH to order
- Climonorm tablets Climonorm tablets, coated tablets No. 21 Germany, Bayer Weimar 331 UAH order
- Klimonorm No. 21 dragees Bayer Weimar GmbH and Co.KG. (Germany) 4 tenge to order