Depo Provera


The medicine contains in its composition such an active substance as medroxyprogesteroneas acetate.

In addition, the following additional components are present in it: polyethylene glycol 3350, sodium chloride, methyl paraben, polysorbate 80, propyl paraben, water for injection.

Release form

Available in the form of a sterile suspension for internal administration.

Pharmachologic effect

Gestagen and antitumor agent.

Pharmacodynamics and pharmacokinetics

Depo-Provera with intramuscular administration is characterized by a long-lasting effect. However, it does not have androgenic and estrogenic activity. This tool blunts pituitary gonadotropin secretiondue to which female patients do not mature follicles and lingers ovulation. It also discourages secretory changes. endometriumincreases viscosity cervical mucus and the number of intermediate cells in the maturation index vaginal epitheliumrelieves vasomotor symptoms during menopause.

If Depo-Provera is used to protect against pregnancy, the risk of developing inflammatory processes in the reproductive system is noticeably reduced vulvovaginal candidiasis. In addition, partial or complete regression of endometrial hyperplastic processes is possible.

In men, a decrease in activity Leydig cells, which leads to a decrease endogenous testosterone secretion.

The antitumor effect of the drug is characterized by a complex effect on pituitary, steroid hormone metabolism at the tissue level and estrogen receptors. In high doses, it has GCS activity.

The maximum plasma concentration of the active component is observed 4-20 days after the first dose. Its connection with plasma proteins is about 95%.

Medroxyprogesterone Acetate well through blood-brain barrier. Cleaves to form metabolites. It is excreted mainly with feces and bile in the form of metabolites or unchanged. About 44% is excreted unchanged in urine. The elimination half-life is six weeks.

Indications for use

In gynecology, this tool is used for:

  • treatment endometriosis;
  • contraception;
  • treatment vasomotor manifestations during the period menopause.

In oncology, the drug is prescribed for metastases and / or relapses kidney cancer, endometrium, breast, prostate gland.


The medicine can not be used for:

  • hypersensitivity to its components;
  • severe violations in the liver;
  • malignant neoplasms mammary gland (if prescribed as a contraceptive);
  • of pregnancy and vaginal bleeding unknown etiology.

In addition, this tool should not be used until the onset of the menstrual cycle. It is also prescribed with caution when epilepsy, chronic renal and heart failure, bronchial asthmadepressive conditions diabetes, migraine.

Side effects

When taking this drug, the following adverse reactions may occur:

  • By CNS: dizziness, crampsfatigue, dull concentration, irritability, vision problems, depression, headache, euphoria, insomnia, drowsiness.
  • By genitourinary system: amenorrhea, pelvic pain, menstrual irregularities and cervical secretion, leukorrhealong anovulation, vaginitis.
  • By STS: cerebral infarction and myocardiumincreased blood pressure thrombosis retinal arteries tachycardia, thromboembolic complications, heart failure, palpitation, thromboembolism, thrombophlebitis.
  • By mucous membranes and skin: acne, hirsutismrash alopecia, itchy skin, hives.
  • Milk glands: galactorrheahypersensitivity mammalgia.
  • By Gastrointestinal tract and liver: constipation, impaired liver function, nausea, dry mouth, flatulence, diarrhea, cholestatic jaundice, vomiting, pain and discomfort in the abdomen.
  • By hematopoietic organs: level up white blood cells and platelet count.
  • Allergy: hypersensitivity, anaphylaxis.
  • Other: pain at the injection site, fever, decreased libido, flushing, peripheral swellingweight change anorgasmia.

Instructions for use Depo-Provera (Method and dosage)

The instruction on Depo-Provera advises to shake a disposable syringe or bottle before use to obtain a homogeneous suspension. Be sure to follow the rules. asepsis.

The drug is usually administered in deltoid or buttock muscle.

The duration of treatment and dosage are determined after consulting a doctor individually.

In the presence of breast cancer in most cases, apply 500-1000 mg per day for 28 days. After which the drug is administered at 500 mg 2 times in 7 days. The course of treatment lasts until the desired therapeutic effect is achieved.

In the presence of kidney cancer and endometriumAs a rule, 400-1000 mg is prescribed once every 7 days. With the onset of improvement, you can switch to a dosage of 400 mg once a month.

In the presence of metastasis cancer prostate gland specialists usually prescribe 500 mg for injections 2 times in 7 days for three months. Then administered 500 mg once every 7 days.

For therapy during postmenopausal women prescribe a short course under the supervision of a doctor.

At endometriosisas a rule, take 50 mg once every 7 days or 100 mg once every 2 weeks. The course is usually designed for six months.

In the presence of vasomotor manifestations during menopause 150 mg once every 12 weeks is prescribed.

For contraception use 150 mg once every 3 months. The first injection is carried out within 1-5 days of the normal menstrual cycle or 5 days after childbirth (if not breastfeeding) In addition, Depo-Provera can be prescribed after cessation of breastfeeding or 6 weeks after birth (if breastfeeding cannot be avoided). In this case, it is necessary to exclude the presence of malignant tumors of the mammary glands and cervix. To protect against unwanted pregnancy, the instructions for the use of Depo-Provera recommends injections with an interval of 12 weeks.


In the treatment of malignant neoplasms in case of exceeding the dose, symptoms that resemble manifestations may be observed overdose of corticosteroids. It is recommended to carefully monitor the condition of patients and, if necessary, adjust the dosage.

Cases of acute overdose are not recorded.


Together with Aminoglutethimide possibly a decrease in the concentration of Depo-Provera in blood plasma and a decrease in efficiency Aminoglutethimide.

Terms of sale

Available in pharmacies only by prescription.

Storage conditions

The medicine must be kept in a dry place, protected from direct sunlight. Optimum temperature - no more than 25 ° С.

Shelf life

Store the drug for no longer than five years.

Depo Provera reviews

Women use this tool mainly for contraception. It is about this action that you can often find reviews about Depo-Provera, 150 mg every 3 months are really effective. However, in many cases, with the use of this medication, complications are observed in the form of gaining excess weight and other adverse reactions.

Reviews of doctors about Depo-Provera can be found different. Someone recommends this remedy to many of their patients, and someone, on the contrary, tries to prescribe it only to women in age. After all, numerous reviews indicate that often this drug can cause complications during pregnancy or make it difficult to conceive a child even after a long time.

Someone even runs the risk of using this drug for cats as a method of contraception. However, it is not without consequences for animals. Experienced breeders claim that 90% of cats after such an injection will remain sterile forever.

Depo-Provera price, where to buy

The price of Depo-Provera 500 mg is about 215 rubles, and in packages of 150 mg - about 160 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine

Pharmacy Dialog

  • Depo-Provera Injection Suspension 150mg / ml vial 3.3ml197 rub.order
  • Depo-Provera suspension for injection 150mg / ml bottle 1ml95 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Depo-Prover suspension for intramuscular injection of 150 mg / ml 1 ml No. 1 flPfizer MFG. Belgium N.V. 113 rubles. Order
  • Depo-prover suspension for intramuscular injection of 150 mg / ml 3.3 ml n1 flPfizer MFG. Belgium N.V. 211 rub.order
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  • Depo-checker 500 mg / 3.3 ml suspension for injection Pfizer Menufecuring Belgiya N.V., Belgium 360 UAH order
  • Depo-checker 150 mg / 1 ml suspension for injection Pfizer Menufechuring Belgiya N.V., Belgium 159 UAH.order

Pani Pharmacy

  • Depo-checker bottle Depo-checker suspension for injection 500mg / 3.3ml Belgium, Pfizer Manufacturing Belgium 402 UAH order
  • Depo-checker bottle Depo-checker suspension water 150mg / ml bottle Belgium, Pfizer Manufacturing Belgium 183 UAH order
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Watch the video: Depo-Provera Shot Side Effects, Schedule & More (February 2020).

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